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Post-op Pain | Adductor Canal Nerve Block Following Total Knee Arthroplasty

Post-op Pain research study

What is the primary objective of this study?

The purpose of this study is that an adductor canal nerve block (putting numbing medicine near the nerve) has been shown to produce excellent pain relief with less pain medication use after knee replacement surgery.The investigators will be comparing the amount of pain relief following knee replacement surgery when you have a nerve block in place. There will be approximately 66 subjects participating in this study. After surgery subjects will receive numbing medication every 6 hours for 48 hours. Subjects will also receive a morphine PCA (patient controlled analgesia) after surgery and pain medication by mouth every 4 hours around the clock with the option to receive more pain medication if needed. Subjects will participate in the study up to 3 days.

Who is eligible to participate?

Inclusion Criteria: 1. Is the subject undergoing primary unilateral total knee arthroplasty? 2. Is the subject 18 to 99 years of age? 3. Is the subject ASA class 1, 2, or 3? 4. Does the subject have a BMI less than 35? 5. Can the subject consent in the English language? Exclusion Criteria: 1. Does subject have an allergy to drugs used in this study; 2. Does subject have a daily intake of opiate medications that are considered stronger than hydrocodone? 3. Does subject have a history of alcohol or drug abuse 4. Has subject had a previous total knee arthroplasty? 5. Has subject had any neurologic deficits in the lower extremity being studied?

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Post-op Pain

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:Morphine PCA started at the end of surgery, 1 Percocet 1/325mg every 4 hours; may receive a second Percocet if needed.

Drug:For the 30ml ropivacaine the intervention would be the subject can request extra pain medication which would be Percocet and/or morphine PCA.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

15ml ropivacaineDepending on what dose of ropivacaine the subject is randomized to he/she could receive the 15ml dose injected into the catheter every 6 hours

30ml ropivacaineIf the subject is randomized to 30ml ropivacaine he/she will be injected through the catheter every 6 hours.

Study Status

Active, not recruiting

Start Date: September 2013

Completed Date: August 2018

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Total Opiate pain medication

Secondary Outcome: Patient satisfaction with pain control

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: Loma Linda University

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01939379

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