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Pneumonia, Bacterial | Surveillance of Hospitalised Pneumonia and Bacterial Meningitis in Tône District, Togo, 2010-2013

Pneumonia, Bacterial research study

What is the primary objective of this study?

The aim of this study is to estimate the burden of disease due to pneumococci, other bacteria and viruses in the African meningitis belt prior to pneumococcal conjugate vaccine introduction and to estimate the population impact of the vaccine after its implementation in 2014. In a defined population of a sanitary district in northern Togo, during the period 2010 to 2017, investigators enroll patients of all ages with suspected pneumonia requiring hospitalization or suspected bacterial meningitis. Patients are evaluated by bacteriology and molecular biology techniques on blood, cerebro-spinal fluid, nasal aspirates and by chest X-ray.

Who is eligible to participate?

Pneumonia surveillance: Inclusion Criteria: - resident of Tône sanitary district - requiring hospitalisation for at least one night for clinical pneumonia syndrome - hospitalised in a study site during the study period Exclusion Criteria: - absence of informed consent by patient or legal tutor Meningitis surveillance: Inclusion Criteria: - resident of Tône sanitary district - presenting clinical signs of acute bacterial meningitis - hospitalised in a study site during the study period Exclusion Criteria: - absence of informed consent by patient or legal tutor

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Pneumonia, Bacterial

Pneumonia, Viral

Meningitis, Bacterial

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Study Status

Recruiting

Start Date: April 2010

Completed Date: June 2017

Phase:

Type: Observational

Design:

Primary Outcome: Incidence of pneumococcal pneumonia requiring hospitalisation, confirmed by blood culture or PCR analysis of blood

Secondary Outcome: Incidence of radiologically confirmed pneumonia requiring hospitalisation

Study sponsors, principal investigator, and references

Principal Investigator: Jennifer C Moïsi, PhD

Lead Sponsor: Agence de Médecine Préventive, France

Collaborator: Region Sanitaire des Savanes, Togo

More information:https://clinicaltrials.gov/show/NCT01747369

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