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Pneumonia | PK Analysis of Moxifloxacin in the Treatment of CAP

Pneumonia research study

What is the primary objective of this study?

At the Department of Infectious Diseases, Aarhus Denmark, moxifloxacin is used in the empirical treatment of severe community-acquired pneumonia (CAP). This study was designed to determine the pharmacokinetics of moxifloxacin 400 mg/day to patients treated empirically for CAP. To accomplish this aim, we established a pharmacokinetic population model. This approach was adopted with the dual purpose of assessing the potential efficacy of the drug and performing Monte-Carlo simulations to characterize the maximal MICs for which recommended pharmacokinetic-pharmacodynamic (PK-PD) targets are obtained for pathogens commonly known to cause CAP.

Who is eligible to participate?

Inclusion Criteria: - Patients with community-acquired pneumonia, treated with moxifloxacin Exclusion Criteria: - Under 18 years of age

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Pneumonia

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Pharmacokinetics MoxifloxacinPatients with community-acquired pneumonia treated with moxifloxacin

Study Status

Completed

Start Date: April 2013

Completed Date: October 2014

Phase:

Type: Observational

Design:

Primary Outcome: Total Peak Plasma Concentration (Cmax)

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Eskild Petersen, MD, Assoc. Prof., D.Sc.

Lead Sponsor: University of Aarhus

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01983839

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