Hypertension | Effects of Potassium Salts on Blood Pressure and Target Organ Damage
Hypertension research study
What is the primary objective of this study?
The purpose of this study is to determine the effect of potassium chloride and potassium bicarbonate on blood pressure and also to determine whether increasing potassium intake has beneficial effects on the surrogate markers of target organ damage in cardiovascular disease, as well as on bone health.
Who is eligible to participate?
Inclusion Criteria: - Patients with untreated essential hypertension (sitting systolic blood pressure between 140 and 170 mmHg and/or sitting diastolic blood pressure between 90 and 105 mmHg); - Age 18 - 75 years. Exclusion Criteria: - Individuals younger than 18 or older than 75 years; - Individuals with impaired renal function with plasma creatinine greater than 120 umol/L for non-blacks or 150 umol/L for blacks; - Individuals with chronic diarrhea, or history of peptic ulcer; - Individuals with baseline plasma potassium values greater than 5.0 mmol/L; - Individuals with severe hypertension i.e. blood pressure > 170/105 mmHg; - Individuals with diabetes mellitus; - Individuals with any secondary cause of hypertension; - Individuals with malignancy or liver disease; - Individuals with ischaemic heart disease or heart failure; - Females who are pregnant or breast feeding or on the oral contraceptive pill.
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Start Date: January 2005
Completed Date: March 2008
Phase: Phase 3
Primary Outcome: Blood pressure and markers of target organ damage and bone health at 4 weeks of potassium supplementation.
Secondary Outcome: Comparisons among different treatments in blood pressure and markers of target organ damage and bone health.
Study sponsors, principal investigator, and references
Principal Investigator: Graham A MacGregor, MD
Lead Sponsor: St George's, University of London