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Condition Requiring Rapid Transfusion During Liver Transplantation Surgery | Effect of Rapid Transfusion With Fluid Management System (FMS) on Plasma Potassium in Liver Transplantation Recipients

Condition Requiring Rapid Transfusion During Liver Transplantation Surgery research study

What is the primary objective of this study?

Rapid infusion of red blood cells is known to result in hyperkalemia in the body. However, potassium concentration in the blood mixture (usually made of RBC, FFP and normal saline) in the reservoir of rapid infusion system and its effect on the plasma potassium change during rapid transfusion are unknown. This study is designed to investigate these changes while massive transfusion is performed during liver transplantation surgery.

Who is eligible to participate?

Inclusion Criteria: - preoperative anemia (hemoglobin < 10 g/dl) - preoperative coagulopathy Exclusion Criteria: - children under age 18 - low risk of intraoperative bleeding

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Condition Requiring Rapid Transfusion During Liver Transplantation Surgery

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Potassium concentrationplasma potassium concentrations in the Fluid Management System (FMS) reservoir, arterial blood, and central venous blood

Study Status

Completed

Start Date: October 2011

Completed Date: April 2016

Phase:

Type: Observational

Design:

Primary Outcome: potassium concentration in the Fluid Management System (FMS) reservoir

Secondary Outcome: plasma potassium of the patient

Study sponsors, principal investigator, and references

Principal Investigator: Chul-Woo Jung, MD. PhD

Lead Sponsor: Seoul National University Hospital

Collaborator: Seoul National University

More information:https://clinicaltrials.gov/show/NCT01331889

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