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Prehypertension | Combined Dietary Education of Low Sodium and High Potassium Consumption

Prehypertension research study

What is the primary objective of this study?

Reduction in sodium consumption is important approach in public health care. In general population, reduction of sodium intake can reduce the future development of hypertension and cardiovascular event. Meanwhile, enhancement of potassium consumption is also important to reduce blood pressure and cardiovascular events. We hypothesized that combined education of low sodium and high potassium consumption is more effective in reducing blood pressure compared to dietary education of low sodium consumption only. The present survey study was designed to test the effectiveness of combined education of low sodium and high potassium consumption in blood pressure reduction and improvement of other variables.

Who is eligible to participate?

Inclusion Criteria: 1. Prehypertension: with a systolic pressure from 120 to 139 mm Hg or a diastolic pressure from 80 to 89 mm Hg 2. Stage 1 hypertension: with a systolic pressure from 140 to 159 mm Hg or a diastolic pressure from 90 to 99 mm Hg Exclusion Criteria: 1. Urinary tract disease 2. Secondary hypertension 3. Previous history of unstable angina, heart failure, myocardial infarction, coronary revascularization, cerebrovascular disease within 12 months 4. Ventricular tachycardia, atrial fibrillation and flutter 5. Hypertrophic cardiomyopathy 6. Known chronic kidney disease: serum creatinine = or > 2.0 mg/dL 7. Hypokalemia (<3.5 mmol/L) or hyperkalemia (>5.5 mmol/L) 8. Type 1 diabetes mellitus 9. Poorly controlled diabetes mellitus (HbA1C = or > 9%) 10. Unable to collect 24 hour urine sample 11. Pregnancy 12. Alcoholics 13. Severe liver disease 14. Night workers 15. Mental retardation

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Prehypertension

Hypertension

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Behavioral:dietary education of low sodium and high potassium consumption

Behavioral:dietary education of low sodium consumption only

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Group 1dietary education of low sodium and high potassium consumption

Group 2dietary education of low sodium consumption only

Study Status

Unknown status

Start Date: March 2013

Completed Date: December 2014

Phase: N/A

Type: Interventional

Design:

Primary Outcome: changes of 24-hour ambulatory systolic and diastolic blood pressure

Secondary Outcome: changes of 24-hour urine sodium and potassium excretion

Study sponsors, principal investigator, and references

Principal Investigator: Moo-Yong Rhee, MD, PhD

Lead Sponsor: DongGuk University

Collaborator: Ministry of Food and Drug Safety, Korea

More information:https://clinicaltrials.gov/show/NCT01914224

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