Prehypertension | Combined Dietary Education of Low Sodium and High Potassium Consumption
Prehypertension research study
What is the primary objective of this study?
Reduction in sodium consumption is important approach in public health care. In general population, reduction of sodium intake can reduce the future development of hypertension and cardiovascular event. Meanwhile, enhancement of potassium consumption is also important to reduce blood pressure and cardiovascular events. We hypothesized that combined education of low sodium and high potassium consumption is more effective in reducing blood pressure compared to dietary education of low sodium consumption only. The present survey study was designed to test the effectiveness of combined education of low sodium and high potassium consumption in blood pressure reduction and improvement of other variables.
Who is eligible to participate?
Inclusion Criteria: 1. Prehypertension: with a systolic pressure from 120 to 139 mm Hg or a diastolic pressure from 80 to 89 mm Hg 2. Stage 1 hypertension: with a systolic pressure from 140 to 159 mm Hg or a diastolic pressure from 90 to 99 mm Hg Exclusion Criteria: 1. Urinary tract disease 2. Secondary hypertension 3. Previous history of unstable angina, heart failure, myocardial infarction, coronary revascularization, cerebrovascular disease within 12 months 4. Ventricular tachycardia, atrial fibrillation and flutter 5. Hypertrophic cardiomyopathy 6. Known chronic kidney disease: serum creatinine = or > 2.0 mg/dL 7. Hypokalemia (<3.5 mmol/L) or hyperkalemia (>5.5 mmol/L) 8. Type 1 diabetes mellitus 9. Poorly controlled diabetes mellitus (HbA1C = or > 9%) 10. Unable to collect 24 hour urine sample 11. Pregnancy 12. Alcoholics 13. Severe liver disease 14. Night workers 15. Mental retardation
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Behavioral:dietary education of low sodium and high potassium consumption
Behavioral:dietary education of low sodium consumption only
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Group 1dietary education of low sodium and high potassium consumption
Group 2dietary education of low sodium consumption only
Start Date: March 2013
Completed Date: December 2014
Primary Outcome: changes of 24-hour ambulatory systolic and diastolic blood pressure
Secondary Outcome: changes of 24-hour urine sodium and potassium excretion
Study sponsors, principal investigator, and references
Principal Investigator: Moo-Yong Rhee, MD, PhD
Lead Sponsor: DongGuk University
Collaborator: Ministry of Food and Drug Safety, Korea