Pruritus | Study of Using Long Acting Antihistamine to Treat Opioid Induced Itching
Pruritus research study
What is the primary objective of this study?
The purpose of this study is determine if long acting antihistamine like cetirizine can help with itching induced by opioid pain medications.
Who is eligible to participate?
Inclusion Criteria: - Children age 6-18yrs on opioids who develop pruritus and are willing to participate in the study Exclusion Criteria: - Children with history of chronic urticaria - Children with other chronic pruritic condition like eczema, contact dermatitis, psoriasis - Children with known hypersensitivity to cetirizine/zyrtec - Children on H1 antihistamine like diphenhydramine, hydroxyzine, cetirizine, loratadine, fexofenadine, chlorpheniramine within the last 7days prior to randomization - Children who have received Ondansetron within 24hrs prior to randomization - Children who are on Tricyclic antidepressants - Children who are unwilling or unable to swallow the capsule. - Children with chronic liver or kidney disease
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:Placebo or sugar pill
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Cetirizinezyrtec 10mg, oral, one time
Sugar pillPlacebo, one pill, one time
Start Date: September 2014
Completed Date: November 2017
Phase: Phase 4
Primary Outcome: Change in Itch Score
Study sponsors, principal investigator, and references
Principal Investigator: Santhosh Kumar, M.D.
Lead Sponsor: Virginia Commonwealth University