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Pruritus | Study of Using Long Acting Antihistamine to Treat Opioid Induced Itching

Pruritus research study

What is the primary objective of this study?

The purpose of this study is determine if long acting antihistamine like cetirizine can help with itching induced by opioid pain medications.

Who is eligible to participate?

Inclusion Criteria: - Children age 6-18yrs on opioids who develop pruritus and are willing to participate in the study Exclusion Criteria: - Children with history of chronic urticaria - Children with other chronic pruritic condition like eczema, contact dermatitis, psoriasis - Children with known hypersensitivity to cetirizine/zyrtec - Children on H1 antihistamine like diphenhydramine, hydroxyzine, cetirizine, loratadine, fexofenadine, chlorpheniramine within the last 7days prior to randomization - Children who have received Ondansetron within 24hrs prior to randomization - Children who are on Tricyclic antidepressants - Children who are unwilling or unable to swallow the capsule. - Children with chronic liver or kidney disease

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Pruritus

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:Cetirizine

Drug:Placebo or sugar pill

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Cetirizinezyrtec 10mg, oral, one time

Sugar pillPlacebo, one pill, one time

Study Status

Terminated

Start Date: September 2014

Completed Date: November 2017

Phase: Phase 4

Type: Interventional

Design:

Primary Outcome: Change in Itch Score

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Santhosh Kumar, M.D.

Lead Sponsor: Virginia Commonwealth University

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01825655

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