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Morphine Adverse Reaction | Prevention of Intrathecal Morphine Induced Pruritus: Comparison of Ondansetron and Palonosetron

Morphine Adverse Reaction research study

What is the primary objective of this study?

Intrathecal administration of morphine is often used for control of postoperative pain. However, pruritus is one of the most common side effects of intrathecal morphine . Specific serotonin receptor antagonists could be an effective prophylactic treatment of neuraxial opioid-induced pruritus. It was reported that palonosetron is more effective than ondansetron for prevention of postoperative nausea and vomiting. Therefore, the investigators evaluated the efficacy of prophylactic administration of ondansetron and palonosetron for the prevention of intrathecal morphine-induced pruritus.

Who is eligible to participate?

Inclusion Criteria: - 19-70 years, - American Society of Anesthesiology physical status 1 and 2 - Scheduled for elective urologic surgery under spinal anesthesia. Exclusion Criteria: - Patients with cardiac and psychological problems. - Patients who take sedatives or narcotics. - Patient who have allergy to study drugs.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Morphine Adverse Reaction

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:Ondansetronintravenous injection

Drug:Palonosetronintravenous injection

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

ondansetronIntravenous administration of ondansetron 4mg 15 minutes before spinal anesthesia

palonosetronIntravenous administration of palonosetron 0.075mg 15 minutes before spinal anesthesia

Study Status

Completed

Start Date: April 2013

Completed Date: June 2014

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Incidence of pruritus

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Younghoon Jeon, Dr

Lead Sponsor: Kyungpook National University

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01952626

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