Left Ventricular Function Systolic Dysfunction | Cardiac Energetics and Function in Normal Human Ageing

Left Ventricular Function Systolic Dysfunction research study

What is the primary objective of this study?

Normal aging is characterized by altered cardiovascular function. Our preliminary data with MR imaging and spectroscopy in normal subjects without cardiovascular disease or hypertension show that age-related cardiac dysfunction is characterized initially by impaired relaxation of the heart (40 - 60 years), and then at > 60 years altered contraction and impaired myocardial energetics. For the first time, the investigators will test whether the functional and energetic effects of normal aging can be reversed by acutely reducing stiffness of peripheral blood vessels using an ACE inhibitor. This will potentially have important insights into how normal aging affects the heart, and how potential treatments could be used to attenuate this process.

Who is eligible to participate?

Inclusion Criteria: - Male and female subjects between the ages of 20 and 80 years Exclusion Criteria: - Any cardiovascular condition including hypertension, or on any cardiovascular therapy. - Blood Pressure > 150 mmHg systolic, and/or > 90 mmHg diastolic - Claustrophobia - Implanted metal prosthesis - Chronic renal failure requiring dialysis - Diabetes mellitus.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Left Ventricular Function Systolic Dysfunction

Left Ventricular Function Diastolic Dysfunction


Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:RamiprilRamipril in one dose to reduce vascular stiffness to determine effects of this on left ventricular function and energetics

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

RamiprilThose who are 40 years and older receive an ACE inhibitor to determine if this reduces age-related changes in left ventricular energetics and function

Study Status


Start Date: July 2012

Completed Date: December 2015

Phase: N/A

Type: Interventional


Primary Outcome: Vascular Stiffness

Secondary Outcome: Effects of ACE inhibitor on left ventricular energetics and function in those subjects aged 40 and over

Study sponsors, principal investigator, and references

Principal Investigator: Guy A MacGowan, MD

Lead Sponsor: Newcastle-upon-Tyne Hospitals NHS Trust


More information:

Hollingsworth KG, Blamire AM, Keavney BD, Macgowan GA. Left ventricular torsion, energetics, and diastolic function in normal human aging. Am J Physiol Heart Circ Physiol. 2012 Feb 15;302(4):H885-92. doi: 10.1152/ajpheart.00985.2011. Epub 2011 Dec 16.

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