Complex Regional Pain Syndromes | The Use of Zoledronic Acid to Complex Regional Pain Syndrome
Complex Regional Pain Syndromes research study
What is the primary objective of this study?
To evaluate the efficacy and the safety of using a single, intravenous 5mg dose of zoledronic acid in managing pain in Complex Regional Pain Syndrome patients.
Who is eligible to participate?
Inclusion Criteria: 1. Patients over 18 years of age of both genders, with continuing pain that is disproportionate to any inciting event, with cardinal features of CRPS. 2. Pain - after initial injury with signs and symptoms present at first visit 3. History of previous unsuccessful treatment for pain, with a minimum of two drug therapies, such as non steroidal anti-inflammatory drugs, steroids, antidepressants, central acting analgesics, calcitonin or sympathetic blocks, (not bisphosphonates) for at least six months. 4. Must report at least one symptom in three of the four following categories: 1. Sensory: Reports of hyperesthesia and/or allodynia 2. Vasomotor: Reports of temperature asymmetry and/or skin color changes and/or skin color asymmetry 3. Sudomotor/Edema: Reports of edema and/or sweating changes and/or sweating asymmetry 4. Motor/Trophic: Reports of decreased range of motion and/or motor dysfunction (weakness, tremor, dystonia) and/or trophic changes (hair, nail, skin). 5. Must display at least one sign* at time of evaluation in two or more of the following categories: 1. Sensory: Evidence of hyperalgesia (to pinprick) and/or allodynia (to light touch and/or deep somatic pressure and/or joint movement) 2. Vasomotor: Evidence of temperature asymmetry and/or skin color changes and/or asymmetry 3. Sudomotor/Edema: Evidence of edema and/or sweating changes and/or sweating asymmetry 4. Motor/Trophic: Evidence of decreased range of motion and/or motor dysfunction (weakness, tremor, dystonia) and/or trophic changes (hair, nail, skin). 6. Skin temperature of the affected side equal or higher than on the non-affected side. 7. No other diagnosis better explains the signs and symptoms. Exclusion Criteria: 1. Presence of systemic diseases including diabetes mellitus, hyperthyroidism, renal and liver dysfunction, peripheral vascular or cardiovascular diseases, uncontrolled hypertension, rheumatoid and hematopoietic diseases, neurological diseases not related to CRPS, overt alcohol addiction, positive pregnancy test and/or lactating women, hyperparathyroidism, and hypocalcaemia. 2. Creatinine clearance <35mL/min, with serum creatinine measured before the dose of zoledronic acid. 3. Pre-existing hypocalcaemia and disturbance of mineral metabolism (e.g. hyperparathyroidism, thyroid surgery, parathyroid surgery, malabsorption syndromes, and excision of small intestine). 4. Hypersensitivity to zoledronic acid or any component drugs used in the trial. 5. Patients with asthma and aspirin-sensitivity 6. Pregnancy or unwillingness to use contraceptive methods during the trial 7. Patients who have previously used any kind of bisphosphonate, especially zoledronic acid. 8. Osteoporosis
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Complex Regional Pain Syndromes
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:Zoledronic acidOne single dose of 5mg intravenous infusion of zoledronic acid (interventional group)
Drug:Placeboone single intravenous infusion of 100ml of saline.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
SalineOne single intravenous infusion of 100ml of saline (placebo control group).
Zoledronic acidone single dose of 5mg intravenous infusion of zoledronic acid (interventional group)
Start Date: December 2013
Completed Date: December 2016
Phase: Phase 2
Primary Outcome: Pain measured on Visual Analog Scale
Secondary Outcome: Lower Limbs vertical force on Wii platform
Study sponsors, principal investigator, and references
Principal Investigator: Linamara R. Battistella, PHD
Lead Sponsor: University of Sao Paulo General Hospital