Post Operative Cognitive Dysfunction | Reversal of General Anesthesia With Methylphenidate
Post Operative Cognitive Dysfunction research study
What is the primary objective of this study?
The aim of this study is to investigate whether methylphenidate (Ritalin) can actively induce
emergence from general anesthesia in patients having a pancreaticoduodenectomy (Whipple
procedure), a pancreatectomy, or a prostatectomy.
Who is eligible to participate?
- Age 18-75 years
- American Society of Anesthesiologists classification 1 or 2
- Scheduled to undergo a pancreaticoduodenectomy or distal pancreatectomy at
Massachusetts General Hospital
- American Society of Anesthesiologists physical status classification of 3 or beyond.
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Post Operative Cognitive Dysfunction
Emergence From Anesthesia
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Enrolling by invitation
Start Date: November 2014
Completed Date: December 2018
Phase: Phase 1/Phase 2
Primary Outcome: Number of Participants with Adverse Events as a Measure of Safety and Tolerability
Secondary Outcome: Time to emergence from general anesthesia
Study sponsors, principal investigator, and references
Lead Sponsor: Massachusetts General Hospital