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Post Operative Cognitive Dysfunction | Reversal of General Anesthesia With Methylphenidate

Post Operative Cognitive Dysfunction research study

What is the primary objective of this study?

The aim of this study is to investigate whether methylphenidate (Ritalin) can actively induce emergence from general anesthesia in patients having a pancreaticoduodenectomy (Whipple procedure), a pancreatectomy, or a prostatectomy.

Who is eligible to participate?

Inclusion Criteria: - Age 18-75 years - American Society of Anesthesiologists classification 1 or 2 - Scheduled to undergo a pancreaticoduodenectomy or distal pancreatectomy at Massachusetts General Hospital Exclusion Criteria: - American Society of Anesthesiologists physical status classification of 3 or beyond.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Post Operative Cognitive Dysfunction

Emergence From Anesthesia

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:Methylphenidate

Other:Saline

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

MethylphenidateMethylphenidate

placeboSaline

Study Status

Enrolling by invitation

Start Date: November 2014

Completed Date: December 2018

Phase: Phase 1/Phase 2

Type: Interventional

Design:

Primary Outcome: Number of Participants with Adverse Events as a Measure of Safety and Tolerability

Secondary Outcome: Time to emergence from general anesthesia

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: Massachusetts General Hospital

Collaborator:

More information:https://clinicaltrials.gov/show/NCT02051452

Discuss Ritalin