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Atrophy | Muscle Atrophy in Sepsis

Atrophy research study

What is the primary objective of this study?

Severe sepsis will provoke signals leading to muscle atrophy and weakness. Electrical stimulation will reduce the impact of sepsis.

Who is eligible to participate?

Inclusion Criteria: - Severe sepsis for < 72hr

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Atrophy

Sepsis

Weakness

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Study Status

Withdrawn

Start Date: December 2007

Completed Date: December 2009

Phase:

Type: Observational

Design:

Primary Outcome: Electrical stimulation will be associated with upregulation of anabolic signaling molecules and genes, downregulation of catabolic signaling molecules and genes within skeletal muscle of patients with sepsis

Secondary Outcome: Electrical stimulation will be associated with improvement of histologic and electrophysiologic and strength parameters within skeletal muscle of patients with sepsis

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: Gregory A. Schmidt

Collaborator:

More information:https://clinicaltrials.gov/show/NCT00583206

Discuss Sepsis