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Sepsis | Identification Sepsis Related Single Nucleotide Polymorphism (SNP) by Whole Exome Sequencing

Sepsis research study

What is the primary objective of this study?

Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. Single nucleotide polymorphism (SNP) was promising genetic biomarker for sepsis patients. The present study was designed to screen several SNP by whole exome sequencing which evaluate the sepsis related snp site in order to be a new target for the treatment of sepsis.

Who is eligible to participate?

Inclusion Criteria: - Clinical diagnosis of sepsis - Patients who agree with the study Exclusion Criteria: - Aged <18 years; - Into the group who died within 24 hours; - Agranulocytosis (<0.5 × 109 / L); - Combined HIV infection.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Sepsis

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

normal control

Sepsis group

Study Status

Unknown status

Start Date: January 2013

Completed Date: December 2015

Phase:

Type: Observational [Patient Registry]

Design:

Primary Outcome: sepsis related SNP site

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Huijuan Wang, Dr

Lead Sponsor: Chinese PLA General Hospital

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01920217

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