Hypertension, Pulmonary | Simvatstatin Used to Treat Pulmonary Hypertension

Hypertension, Pulmonary research study

What is the primary objective of this study?

we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.

Who is eligible to participate?

Inclusion Criteria: - pasp>50mmHg Exclusion Criteria: - pasp<50mmhg

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Hypertension, Pulmonary

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:simvastatinmedication with simvastation on the dosage of 40mg per day before the operation and all the time after the operation

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

1simvastatin groupbefore the operation, the patient start the simvastatin medication on the dosage of 40mg per day

2contral groupjust do routin operation with no use of simvastatin, other medication is exact the same as the simvastatin group

Study Status

Unknown status

Start Date: January 2009

Completed Date: January 2012

Phase: Phase 1

Type: Interventional


Primary Outcome: the simvastatin can alleviate pulmonary hypertension

Secondary Outcome: simvastatin can highten the perioperative and long term survaval rate and the living quality

Study sponsors, principal investigator, and references

Principal Investigator: Huili Gan, MD,Ph.D.

Lead Sponsor: Capital Medical University


More information:

Discuss Simvastatin