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Chronic Sinusitis | Nasal Packing as a Drug Delivery System Postoperatively in Chronic Sinusitis With Polyposis

Chronic Sinusitis research study

What is the primary objective of this study?

That high-dose steroid applied to the nasal cavity immediately post-operatively will improve olfaction and healing following endoscopic sinus surgery.

Who is eligible to participate?

Inclusion Criteria: - hyposmia and nasal obstruction for >12 weeks - bilateral nasal polyposis - candidate for surgery Exclusion Criteria: - immunocompromised - non-English speaking - prisoner - pregnant/lactating - will not attend follow up appointments

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Chronic Sinusitis

Polyposis

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:pulmicortapplied to nasal packing after surgery

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Single Arm; nostrils as experimental and comparatoreach subject serves as their own control with one nostril being treated with pulmicort and one not

Study Status

Completed

Start Date: September 2010

Completed Date:

Phase: Phase 3

Type: Interventional

Design:

Primary Outcome: olfaction

Secondary Outcome: Sinonasal health

Study sponsors, principal investigator, and references

Principal Investigator: Garrett R Griffin, MD

Lead Sponsor: University of Michigan

Collaborator: American Rhinologic Society

More information:https://clinicaltrials.gov/show/NCT01197612

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