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Sinusitis | Association of Periostin Levels and Chronic Sinusitis

Sinusitis research study

What is the primary objective of this study?

The purpose of this study is to see if a protein in blood, called periostin, can determine if patients have chronic sinusitis. This protein is in everyone's body, but the level of the protein may indicate certain conditions such as chronic sinusitis. The investigators are interested in testing levels of periostin to see if they are higher or lower than patients without chronic sinusitis, just as periostin is higher in patients with asthma. All patients enrolled in this study will have chronic sinusitis without asthma.

Who is eligible to participate?

Inclusion Criteria: - Patients with sinus disease which requires surgical intervention - Ability to understand and give informed consent Exclusion Criteria: - Previous diagnosis of asthma - Positive methacholine challenge at screening - Diagnosis of cystic fibrosis - Concomitant use of systemic corticosteroids (except for those prescribed as part of standard pre-surgical treatment)

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Sinusitis

Nasal Polyps

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:Blood draw

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Subjects who require sinus surgery

Study Status

Withdrawn

Start Date: September 2014

Completed Date: October 2016

Phase: N/A

Type: Observational

Design:

Primary Outcome: Difference in circulating serum periostin levels pre and post sinus surgery

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: University of Virginia

Collaborator:

More information:https://clinicaltrials.gov/show/NCT02071667

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