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Anxiety | Depression and Anxiety Reduction Treatment for Suicide

Anxiety research study

What is the primary objective of this study?

The purpose of this study is to test the effectiveness and usability of multiple computer-based treatments for mood and anxiety relevant risk factors. The target of the treatment is related to cognitive stress, which has been shown to be associated with a variety of negative mental health outcomes such as Post-Traumatic Stress Disorder, suicidal ideation, and substance use disorders.

Who is eligible to participate?

Inclusion Criteria: - At or above community sample mean on ASI-3 - At or above community sample mean on INQ-R - English speakers - 18 years of age or older Exclusion Criteria: - Significant medical illness - Current substance dependence - Current or past psychotic-spectrum disorders - Uncontrolled bipolar disorder - Serious suicidal intent that warranted immediate treatment

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Anxiety

Depression

Suicide

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Behavioral:Psychoeducation and Cognitive Bias Modification

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Anxiety Risk ReductionThe anxiety risk reduction condition will be a combination of psychoeducation plus Cognitive Bias Modification (CBM-I) for anxiety sensitivity (AS). The psychoeducational component will focus on the nature of stress and its effect on the body. Interoceptive exposure (IE) exercises, designed to correct the conditioned fear to these bodily sensations, will be explained and practiced.

Mood Risk ReductionThe mood risk reduction condition will be a combination of psychoeducation plus Cognitive Bias Modification (CBM-I) for perceived burdensomeness and thwarted belongingness. The psychoeducational component will focus on dispelling myths related to burdensomeness and belongingness and describe their role in the development of mood symptoms.

Combined Risk ReductionThe combined intervention will involve all of the interventions in the anxiety and mood risk reduction conditions and thus will not be matched for length.

Repeated Contact ControlParticipants assigned to the repeated contact group will be assigned a "personal" study coordinator. The coordinator will contact them at specific intervals during the study. The rationale for these contacts will be provided (e.g., checking in on their status and helping to administer some brief measures). During the three weeks (corresponding to treatment session intervals for those in one of the active treatment conditions), the study coordinator will contact the participant once per week for a brief phone check in where suicide risk will be evaluated. Participants in the control group will also meet with their study coordinator during each of the scheduled follow-up visits.

Study Status

Completed

Start Date: November 2013

Completed Date: September 2017

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Interpersonal Needs Questionnaire (INQ)

Secondary Outcome: Anxiety Sensitivity Index-3 (ASI-3)

Study sponsors, principal investigator, and references

Principal Investigator: Norman B Schmidt, Ph.D.

Lead Sponsor: Florida State University

Collaborator: United States Department of Defense

More information:https://clinicaltrials.gov/show/NCT01941862

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