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Attempt Suicide | Genetic Variants Associated With Adolescent Suicide Attempts

Attempt Suicide research study

What is the primary objective of this study?

Suicidal behaviors is known to aggregate in families. The purpose of this study is to evaluate association between common polymorphisms in genes important for neurobiological pathways linked to suicidal behaviors and suicide attempt among adolescents patient.

Who is eligible to participate?

Inclusion Criteria: Case : - Age at admission between 13 and 17 years old - Hospitalized for attempted suicide - Absence of prominent mental retardation or organic brain damage - Fluent in French - Able to comprehend the study procedures and to undergo entry assessments safely - Provided written informed consent for study participation, and additional consent from the patient's parents or guardians - Northern and Western European ancestry (HapMap-CEU) - Medical insurance coverage Control : - Healthy adult volunteers - No present or past psychiatric illness - No personal history of suicidal behavior and without a family history of suicide - Provided written informed consent for study participation - Northern or Western European ancestry (HapMap-CEU) - Medical insurance coverage Exclusion Criteria: Case: - Inability to get an informed and valid consent - Home address outside the selected hospitals' geographic areas - Intellectual disability or organic brain damage - Origine ethnique non CEU - Absence of medical insurance coverage - Pregnant or lactating women - Without Northern or Western European ancestry (HapMap-CEU) Control : - Inability to get an informed and valid consent - Intellectual disability or organic brain damage - History of suicidal behavior - Psychiatric disorder, past or present - Family history of suicide - Borderline personality disorder - Absence of medical insurance coverage - Pregnant or lactating women - Without Northern or Western European ancestry (HapMap-CEU)

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Attempt Suicide

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Genetic:SNP GenotypingIndividuals were genotyped at a total 96 SNP from 15 candidate gene

Genetic:SNP genotyping

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Inpatient group SNP GenotypingPatients will be recruited from pediatric departments in which 13 -17 y old adolescents are hospitalized for a suicide attempt. Data will be collected through self-administered questionnaires and face to face interview. DNA will be extracted from saliva sample. Individuals will be genotyped at a total of 96 SNPs

Control group SNP GenotypingControl subjects are young adults without suicide attempt and without mental disorders

Study Status

Completed

Start Date: December 2013

Completed Date: July 2016

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Odds ratio (OR) and 95% confidence interval (CI) will be estimated using a logistic regression model to assessing the contribution of each polymorphism as a risk factor in predicting suicidal behavior

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: BOJAN MIRKOVIC, MD

Lead Sponsor: University Hospital, Rouen

Collaborator: Institut National de la Santé Et de la Recherche Médicale, France

More information:https://clinicaltrials.gov/show/NCT02001649

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