Heparin-Induced Thrombocytopenia | Validating 4Ts for Heparin Induced Thrombocytopenia (HIT)
Heparin-Induced Thrombocytopenia research study
What is the primary objective of this study?
The purpose of this study is to evaluate a scoring tool to help determine the presence of Heparin Induced Thrombocytopenia (HIT), which is an adverse reaction to heparin. We hypothesize that this scoring tool will be very useful in excluding patients who are suspected of having HIT.
Who is eligible to participate?
Inclusion Criteria: - Patients with suspected HIT. Exclusion Criteria:
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Other:Scoring 4Ts and Chong scaleTwo physicians will independently score both the 4Ts and the Chong scale on all patients enrolled in this study.
Other:Blood drawPatient serum will be collected to perform Serotonin Release Assay testing to verify the presence of HIT.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Suspected HITThose who are clinically suspected of having HIT will be enrolled in this study.
Start Date: August 2009
Primary Outcome: To validate the 4Ts as a pretest probability tool for HIT.
Secondary Outcome: To determine the inter-rater variability for scoring the 4Ts.
Study sponsors, principal investigator, and references
Principal Investigator: Chee M Chan, MD
Lead Sponsor: Washington Hospital Center
Lo GK, Juhl D, Warkentin TE, Sigouin CS, Eichler P, Greinacher A. Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings. J Thromb Haemost. 2006 Apr;4(4):759-65.