Parkinson's Disease | Imaging in the Diagnosis of Parkinson's Disease and Essential Tremor
Parkinson's Disease research study
What is the primary objective of this study?
Parkinson´s disease (PD) diagnosis is based upon clinical examination. Although imaging has helped doctors to identify many diseases, it still does not add too much information for the diagnosis of Parkinson´s disease. The investigators are going to perform a large sample study including PD patients, essential tremor and healthy volunteers in order to evaluate if MRI can help in the diagnosis. Our hypothesis is that fractional anisotropy (FA) in the caudal portion of substantia nigra is decreased in PD patients.
Who is eligible to participate?
Inclusion Criteria: - Parkinson´s disease patients according to UK Parkinson´s Disease Brain Bank Criteria - Essential Tremor Patients according to Movement Disorder´s diagnosis consensus criteria. - Healthy Volunteers: paired with PD patients by age and gender. Exclusion Criteria: - Contraindication to MRI - Claustrophobia. - Serious structural brain anomalies. - Condition or situation in which, in the opinion of the investigator put the patient at significant risk, which can confound the results, or substantially interfere with the individual's participation in the study.
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Parkinson's diseasePatients with primary Parkinson's disease
Essential tremorPatients with essential tremor
Healthy volunteersHealthy volunteers
Start Date: October 2012
Completed Date: July 2014
Primary Outcome: Fractional anisotropy (FA) in the caudal portion of substantia nigra
Secondary Outcome: Comparison between MRI and ultrasonography
Study sponsors, principal investigator, and references
Principal Investigator: Edson Amaro Junior, MD,PhD
Lead Sponsor: Hospital Israelita Albert Einstein
Collaborator: University of Sao Paulo
Vaillancourt DE, Spraker MB, Prodoehl J, Abraham I, Corcos DM, Zhou XJ, Comella CL, Little DM. High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease. Neurology. 2009 Apr 21;72(16):1378-84. doi: 10.1212/01.wnl.0000340982.01727.6e. Epub 2009 Jan 7. Erratum in: Neurology. 2009 Jun 9;72(23):2059.