Tremor | Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor

Tremor research study

What is the primary objective of this study?

The purpose of this study is to determine the changes in quality of life and degree of tremor for patients with essential tremor or Parkinsonian tremor who are treated by stereotactic radiosurgery (SRS). This is a questionnaire-based study. Please see Detailed Description below for more information.

Who is eligible to participate?

Inclusion Criteria: - Must be certified by a neurologist as having essential tremor or Parkinsonian tremor that is insufficiently controlled by medication alone. - Preference to receive radiation treatment for tremor treatment, rather than surgical DBS implantation or surgical thalamotomy - At least 18 years old Exclusion Criteria: - Contraindications to cranial radiation (such as prior radiation to the thalamus) - Inability to have a MRI of the brain - Prior surgical thalamotomy treatment (but contralateral deep brain stimulator [DBS] is permitted) - Estimated life expectancy less than 1 year

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?


Essential Tremor

Parkinson Disease


Quality of Life

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:Questionnaires / Observational AssessmentsIncludes QUEST, PDQ-39, FTM, and Neuropsych evaluation

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Essential TremorPatients with severe, medication-refractory Essential Tremor

Parkinsonian TremorPatients with severe, medication-refractory, tremor-dominant Parkinsons

Study Status


Start Date: November 2012

Completed Date: June 2023


Type: Observational


Primary Outcome: Quality of Life

Secondary Outcome: Severity of Tremor

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: Vanderbilt University Medical Center


More information:

Discuss Tremors