Essential Tremor | Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography.

Essential Tremor research study

What is the primary objective of this study?

Investigators hypothesize that there are specific characteristic of each cognitive and motor condition that can be defined using brains scans.

Who is eligible to participate?

Inclusion Criteria: - All subjects will be age 40 or older, - Be on stable medications for at least 30 days - Montreal Cognitive Assessment (MOCA) of 26 or higher - Scores within 1.5 standard deviations of age-matched norms for all neuropsychological tests - Parkinson's Plus Disorders (PD) will be defined using United Kingdom (UK) Brain Bank Criteria. - PD dementia (PDD) will be defined using the Movement Disorder Task Force 2007 criteria and supported by scores less than 1.5 standard deviations of age-matched norms in at least two domains. - Probable Alzheimer's Disease (AD) will be defined using the National Institute on Aging-Alzheimer Association 2011 guidelines. - Parkinson's Plus Disorders (PD) with mild cognitive impairment (MCI) will be defined by history, MOCA of 21 or higher, at least one score less than 1.5 standard deviations of age-matched norms, and cannot meet diagnostic criteria for PDD. - Essential tremor and Parkinson plus syndromes (multiple systems atrophy, corticobasal degeneration, progressive supranuclear palsy) will be defined using previously published research criteria.19-22 Exclusion Criteria - Features suggestive of other causes of parkinsonism/Parkinson-plus syndromes; - Features suggestive of other causes of dementia, including moderate to severe cerebrovascular disease by history, or imaging or history of major head trauma; - History of deep brain stimulation, ablation surgery, or other brain surgery; - Evidence for depression based on the Hospital Anxiety Depression Scale (score > 11).

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Essential Tremor

Multiple System Atrophy

Corticobasal Degeneration

Supranuclear Palsy, Progressive

Parkinson Disease

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Study Status


Start Date: November 2013

Completed Date: December 2018


Type: Observational


Primary Outcome: Focal oscillatory activity

Secondary Outcome: Spectral coherence:

Study sponsors, principal investigator, and references

Principal Investigator: Benzi Kluger, MD

Lead Sponsor: University of Colorado, Denver


More information:

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