Odontalgia | Local Anesthesia and Analgesics in Endodontic Pain

Odontalgia research study

What is the primary objective of this study?

For patients with a toothache, is pain relief after root canal procedure improved using long acting local anesthetic and analgesics? The purpose of this clinical trial is the investigate the effect of long acting local anesthetic with 1 of 4 oral medication groups, on post-operative endodontic pain.

Who is eligible to participate?

Inclusion Criteria: 18-65 y.o. American Society of Anesthesiologists physical classification I or II Can understand and complete pain evaluation forms tooth pain (>3 out of 10) needing root canal Ability to read and provide informed consent Must be able to swallow tablets Exclusion Criteria: Allergy/intolerance to analgesics (ibuprofen, naproxen, vicodin) Patients who are pregnant Patients currently on pain medications for an unrelated condition Patients unwilling to fill out pain scales Liver or kidney disease Unable to understand and complete consent form and pain evaluation forms

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?


Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:Oral placeboplacebo

Drug:Oral ibuprofenIbuprofen

Drug:oral naproxennaproxen

Drug:oral acetaminophen/hydrocodone + ibuprofenvicodin/ibuprofen

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Endododontic Tx + Long acting local anestheticlong acting local anesthetic

Endodontic Tx plus local anestheticlocal anesthetic

Study Status


Start Date: February 2014

Completed Date: September 2015

Phase: N/A

Type: Interventional


Primary Outcome: Effect of long acting anesthesia and analgesics on endodontic pain

Secondary Outcome: Effect of gender and age on post-operative endodontic pain treatment

Study sponsors, principal investigator, and references

Principal Investigator: Walter Bowles, DDS

Lead Sponsor: University of Minnesota - Clinical and Translational Science Institute

Collaborator: University of Minnesota, MN

More information:

Discuss Vicodin