Post-operative Vomiting | Does First Oral Intake After Emergence Predict the Incidence of Post-operative Vomiting in Children?
Post-operative Vomiting research study
What is the primary objective of this study?
Second only to pain, nausea and vomiting are the most uncomfortable complications of surgery and anesthesia. Unfortunately, our best defense against post-operative nausea and vomiting, a medicine called ondansetron (Zofran), is in dire national shortage. Consequently, non-pharmacological methods of prevention and treatment for post-operative nausea and vomiting have increased import. Following emergence from general anesthesia, children often request food and drink. There have been no studies to date that definitively determine the optimal first food or drink choice for these children. This study proposes to randomize children to either water or juice first intake following surgery. The investigators expect to find that children who consume glucose are less likely to vomit than those who first receive water.
Who is eligible to participate?
Inclusion Criteria: - Dental surgery - Tonsillectomy and adenoidectomy - Strabismus surgery - Age 2-18 Exclusion Criteria: - Patient refusal - Parent refusal - Allergy / contraindication to ondansetron - Prone to vomiting - Inpatient - Preoperative anxiolysis with ketamine - Recovery location other than PACU - Nil per os at baseline - Presence of enteric tube - Contraindication to any part of the study protocol
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
WaterWater will be given as the study subject's first oral intake after emergence from general anesthesia.
Apple JuiceApple juice will be given as the study subject's first oral intake after emergence from general anesthesia.
Start Date: October 2012
Completed Date: December 2013
Primary Outcome: Post-operative Vomiting
Study sponsors, principal investigator, and references
Principal Investigator: Jamie R Wingate, MD
Lead Sponsor: University of North Carolina, Chapel Hill