Postoperative Nausea and Vomiting | Intravenous Lidocaine in the Prevention of Postoperative Vomiting in Elective Tonsil Surgery

Postoperative Nausea and Vomiting research study

What is the primary objective of this study?

There some evidence regarding the effect of lidocaine for the prevention of nausea and vomiting in adults.

Who is eligible to participate?

Inclusion Criteria: - Children between 2 and 12 years - ASA I or II - Programmed for elective tonsillectomy with or without adenoidectomy under general anesthesia Exclusion Criteria: - Obesity, defined as body mass index (BMI) ≥ 95th percentile for age and sex. - Use of antiemetic drugs during the 24 hours before surgery. - Gastroesophageal reflux. - History of allergy to any of the drugs used in the study. - Down Syndrome.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Postoperative Nausea and Vomiting


Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:LidocaineBolus 1.5 mg/kg over 5 minutes, then an infusion of 2 mg/kg/h

Drug:Normal salineSodium Chloride 0.9% infusion

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Group LGroup L Lidocaine load dose 1.5 mg / kg over 5 minutes, followed by continuous infusion of 2 mg / kg / h, which is maintained until the end of surgical procedure

Group PNormal saline solution administered under the same regimen

Study Status


Start Date: March 2012

Completed Date: June 2013

Phase: Phase 4

Type: Interventional


Primary Outcome: Evaluating the effectiveness of intravenous lidocaine during anesthesia to decrease the numbers of events (vomiting) during the immediate postoperative period up to 24 hours postoperatively, comparing to placebo

Secondary Outcome: The prevention of the composite "nausea / or vomiting"

Study sponsors, principal investigator, and references

Principal Investigator: Fernando R Altermatt, MD

Lead Sponsor: Pontificia Universidad Catolica de Chile


More information:

Discuss Vomiting