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BONE MARROW TRANSPLANT REJECTION side effect

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Busulfan Side Effects Report #5527709-0
Physician from JAPAN reported BUSULFAN problem on Nov 09, 2007. Male patient, child 4 years of age, was diagnosed with stem cell transplant and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: bone marrow transplant rejection, . BUSULFAN dosage: 4.8 MG/KG;QD;IV. During the same period patient was treated with DALTEPARIN. Patient recovered.

Busulfan Side Effects Report #5528071-X
BUSULFAN problem was reported by a Consumer or non-health professional from JAPAN on Nov 09, 2007. Female patient, 17 years of age, was diagnosed with stem cell transplant and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: bone marrow transplant rejection, white blood cell count decreased, . BUSULFAN dosage: 28.4 ML;QV;IV. Patient recovered.

Busulpan Side Effects Report #5466207-X
Consumer or non-health professional from JAPAN reported BUSULPAN problem on Sept 10, 2007. Male patient, 33 years of age, was diagnosed with stem cell transplant and was treated with BUSULPAN. After drug was administered, patient experienced the following problems/side effects: bone marrow transplant rejection, pneumonia staphylococcal, sepsis, stenotrophomonas infection, . BUSULPAN dosage: 24 ML; QD; IV. During the same period patient was treated with VALPROATE, FLUDARABINE PHOSPHATE, LENOGRASTIM, METHOTREXATE, TACROLIMUS. Patient died on 04/22/2007.

Busulfan Side Effects Report #5422196-5
BUSULFAN problem was reported by a Consumer or non-health professional from JAPAN on Aug 03, 2007. Female patient, child 7 years of age, was diagnosed with stem cell transplant and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: bone marrow transplant rejection, bronchopulmonary aspergillosis, cystitis haemorrhagic, erythema, flushing, pigmentation disorder, staphylococcal sepsis, swelling, venoocclusive liver disease, . BUSULFAN dosage: 20 MG/KG; QD; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, ETOPOSIDE, VALPROATE, METHOTREXATE, TACROLIMUS. Patient recovered.


Thymoglobulin Side Effects Report #5794498-4
Physician from NETHERLANDS reported THYMOGLOBULIN problem on June 06, 2008. Female patient, 32 years of age, weighting 127.9 lb, was diagnosed with stem cell transplant, t-cell depletion and was treated with THYMOGLOBULIN. After drug was administered, patient experienced the following problems/side effects: bone marrow transplant rejection, bronchopulmonary aspergillosis, epstein-barr virus infection, multi-organ failure, post transplant lymphoproliferative disorder, . THYMOGLOBULIN dosage: 175 MG, QD, INTRAVENOUS. During the same period patient was treated with BUSULPHAN, FLUDARABINE, CAMPATH. Patient was hospitalized. Patient died on 09/29/2007.

Busulfex Side Effects Report #5798831-9
BUSULFEX problem was reported by a Health Professional from JAPAN on June 16, 2008. Male patient was diagnosed with stem cell transplant and was treated with BUSULFEX. After drug was administered, patient experienced the following problems/side effects: bone marrow transplant rejection, . BUSULFEX dosage: 9.2 ML INTRAVENOUS; 10 ML, DAILY DOSE; INTRAVENOUS. During the same period patient was treated with MELPHALAN, CLONAZEPAM, NEUPOGEN, METHOTREXATE, TACROLIMUS, FLUDARABINE PHOSPHATE. Patient recovered.

Busulfex Side Effects Report #5729831-2
Consumer or non-health professional from JAPAN reported BUSULFEX problem on Apr 22, 2008. Male patient, 23 years of age, was treated with BUSULFEX. After drug was administered, patient experienced the following problems/side effects: bone marrow transplant rejection, convulsion, cytokine storm, diarrhoea, encephalitis viral, engraftment syndrome, graft versus host disease, liver disorder, malaise, . BUSULFEX dosage: 9.4 ML, QID; INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, CYCLOPHOSPHAMIDE, VALPROATE, NARTOGRASTIM, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient died.

Clofarabine Side Effects Report #5722891-4
CLOFARABINE problem was reported by a Health Professional from UNITED STATES on Apr 22, 2008. Female patient was treated with CLOFARABINE. After drug was administered, patient experienced the following problems/side effects: bone marrow transplant rejection, refractoriness to platelet transfusion, . CLOFARABINE dosage: unknown. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5663405-7
Consumer or non-health professional from JAPAN reported BUSULFAN problem on Feb 22, 2008. Female patient, 54 years of age, was diagnosed with stem cell transplant and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: anorexia, bone marrow transplant rejection, diarrhoea, malaise, nausea, stomatitis, vomiting, . BUSULFAN dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, FILGRASTIM, METHOTREXATE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.


Busulfan Side Effects Report #5497643-3
BUSULFAN problem was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Male patient, 49 years of age, was diagnosed with stem cell transplant, graft versus host disease and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: anorexia, bone marrow transplant rejection, central line infection, cytomegalovirus infection, diarrhoea, gamma-glutamyltransferase increased, hyperbilirubinaemia, malaise, pain in extremity, . BUSULFAN dosage: 40 ML;QD;IV. During the same period patient was treated with NARTOGRASTIM, TRIMETHYLCETYLAMMONIUM PENTACHLOROPHENATE, CLADRIBINE, PHENYTOIN, LENOGRASTIM, NEUPOGEN, TACROLIMUS, MYCOPHENOLATE MOFETIL. Patient was hospitalized and became disabled. Patient recovered.

Busulfan Side Effects Report #5406731-9
Consumer or non-health professional from JAPAN reported BUSULFAN problem on July 20, 2007. Female patient, 52 years of age, weighting 132.3 lb, was diagnosed with stem cell transplant and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: blood stem cell transplant failure, bone marrow transplant rejection, haemodialysis, renal failure, sepsis, venoocclusive liver disease, weight increased, . BUSULFAN dosage: 208 MG. Patient was hospitalized. Patient died on 02/09/2007.

Busulfan Side Effects Report #5406807-6
BUSULFAN problem was reported by a Consumer or non-health professional from JAPAN on Aug 01, 2007. Male patient, child 3 years of age, was diagnosed with stem cell transplant and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: anorexia, bone marrow transplant rejection, diarrhoea, hyponatraemia, malaise, nausea, vomiting, . BUSULFAN dosage: 12 ML;QD;IV. During the same period patient was treated with ETOPOSIDE, CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5391695-7
Consumer or non-health professional from JAPAN reported BUSULFAN problem on July 03, 2007. Male patient, 49 years of age, was diagnosed with stem cell transplant, graft versus host disease and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: anorexia, bone marrow transplant rejection, cytomegalovirus infection, diarrhoea, graft complication, hyperbilirubinaemia, malaise, pain in extremity, pseudomembranous colitis, . BUSULFAN dosage: 40 ML; QD; IV. During the same period patient was treated with NARTOGRASTIM, TRIMETHYLCETYLAMMONIUM PENTACHLOROPHENATE, CLADRIBINE, PHENYTOIN, LENOGRASTIM, FILGRASTIM, TACROLIMUS, MYCOPHENOLATE MOFETIL. Patient recovered.

Busulfan Side Effects Report #5391695-7
BUSULFAN problem was reported by a Consumer or non-health professional from JAPAN on July 03, 2007. Male patient, 49 years of age, was diagnosed with stem cell transplant, graft versus host disease and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: anorexia, bone marrow transplant rejection, cytomegalovirus infection, diarrhoea, graft complication, hyperbilirubinaemia, malaise, pain in extremity, pseudomembranous colitis, . BUSULFAN dosage: 40 ML; QD; IV. During the same period patient was treated with NARTOGRASTIM, TRIMETHYLCETYLAMMONIUM PENTACHLOROPHENATE, CLADRIBINE, PHENYTOIN, LENOGRASTIM, FILGRASTIM, TACROLIMUS, MYCOPHENOLATE MOFETIL. Patient recovered.


Busulfex Side Effects Report #5798833-2
Health Professional from JAPAN reported BUSULFEX problem on June 16, 2008. Male patient, 37 years of age, was diagnosed with stem cell transplant and was treated with BUSULFEX. After drug was administered, patient experienced the following problems/side effects: anorexia, bone marrow transplant rejection, diarrhoea, encephalitis viral, engraft failure, gastrointestinal haemorrhage, hepatic failure, pneumonia, . BUSULFEX dosage: 32 ML INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, NEUPOGEN, METHOTREXATE, TACROLIMUS. Patient died.

Busulfex Side Effects Report #5729829-4
BUSULFEX problem was reported by a Consumer or non-health professional from JAPAN on Apr 21, 2008. Female patient, 51 years of age, was treated with BUSULFEX. After drug was administered, patient experienced the following problems/side effects: acute graft versus host disease, bone marrow transplant rejection, disease recurrence, haemorrhage, herpes virus infection, liver disorder, myelodysplastic syndrome, pneumonia, respiratory disorder, . BUSULFEX dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, NEUPOGEN, METHOTREXATE, CYCLOSPORINE, WARFARINPOTASSIUM. Patient died.

Clofarabine Side Effects Report #5736802-9
Health Professional from UNITED STATES reported CLOFARABINE problem on May 01, 2008. Female patient, 60 years of age, weighting 190.9 lb, was diagnosed with myelodysplastic syndrome and was treated with CLOFARABINE. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, bone marrow transplant rejection, decreased appetite, diarrhoea, dry mouth, dyspnoea exertional, fatigue, hyperglycaemia, hypermagnesaemia, . CLOFARABINE dosage: 54 MG, QDX5, INTRAVENOUS. During the same period patient was treated with ACYCLOVIR, ALLOPURINOL, CIPRO, SENNA, PROVERA, ZOFRAN, SIROLIMUS, BACTRIM. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #5698126-8
BUSULFEX problem was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Male patient, 25 years of age, was diagnosed with stem cell transplant and was treated with BUSULFEX. After drug was administered, patient experienced the following problems/side effects: bone marrow transplant, bone marrow transplant rejection, perianal abscess, pneumonia staphylococcal, staphylococcal pharyngitis, stomatitis, surgical procedure repeated, . BUSULFEX dosage: unknown. Patient died.

Busulfex Side Effects Report #5698190-6
Consumer or non-health professional from JAPAN reported BUSULFEX problem on Mar 21, 2008. Male patient, 62 years of age, was diagnosed with stem cell transplant and was treated with BUSULFEX. After drug was administered, patient experienced the following problems/side effects: blood bilirubin increased, bone marrow transplant rejection, . BUSULFEX dosage: unknown. During the same period patient was treated with CEFEPIME HYDROCHLORIDE, CEFTAZIDIME, PAZUFLOXACIN MESILATE, AMOXICILLIN, UNASYN, PHENYTOIN, NEUPOGEN. Patient recovered.


Busulfan Side Effects Report #5369892-6
BUSULFAN problem was reported by a Consumer or non-health professional from JAPAN on June 07, 2007. Male patient, 40 years of age, was diagnosed with stem cell transplant and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: acute graft versus host disease, bone marrow transplant rejection, peritonitis, tumour lysis syndrome, venoocclusive liver disease, . BUSULFAN dosage: 216 MG; QD; IV. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5585760-9
Consumer or non-health professional from JAPAN reported BUSULFAN problem on Dec 21, 2007. Male patient, 24 years of age, was diagnosed with stem cell transplant and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: acute graft versus host disease, anorexia, bone marrow transplant rejection, cytomegalovirus infection, febrile neutropenia, liver disorder, nausea, pancytopenia, stomatitis, . BUSULFAN dosage: 8.13 ML; ; IV. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5497644-5
BUSULFAN problem was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Female patient, 50 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: anorexia, blood potassium decreased, bone marrow transplant rejection, cytomegalovirus infection, gamma-glutamyltransferase increased, ill-defined disorder, mucous membrane disorder, nausea, neutropenia, . BUSULFAN dosage: 26.4 ML;QD;IV. During the same period patient was treated with METHOTREXATE, FLUDARABINE PHOSPHATE, PHENYTOIN, NEUPOGEN. Patient was hospitalized and became disabled. Patient recovered.

Busulfan Side Effects Report #5391696-9
Health Professional from JAPAN reported BUSULFAN problem on July 03, 2007. Female patient, 51 years of age, was diagnosed with stem cell transplant and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: acute myeloid leukaemia, blood pressure decreased, bone marrow transplant rejection, cardiac arrest, condition aggravated, diarrhoea, respiratory arrest, sepsis, . BUSULFAN dosage: 26.68 ML;QD;IV. During the same period patient was treated with VALPROATE, CYCLOPHOSPHAMIDE, METHOTREXATE, CYCLOSPORINE. Patient was hospitalized. Patient died on 04/09/2007.

Busulfan Side Effects Report #5391696-9
BUSULFAN problem was reported by a Health Professional from JAPAN on July 03, 2007. Female patient, 51 years of age, was diagnosed with stem cell transplant and was treated with BUSULFAN. After drug was administered, patient experienced the following problems/side effects: acute myeloid leukaemia, blood pressure decreased, bone marrow transplant rejection, cardiac arrest, condition aggravated, diarrhoea, respiratory arrest, sepsis, . BUSULFAN dosage: 26.68 ML;QD;IV. During the same period patient was treated with VALPROATE, CYCLOPHOSPHAMIDE, METHOTREXATE, CYCLOSPORINE. Patient was hospitalized. Patient died on 04/09/2007.