Thrive – Interesting Facts

Thrive – Interesting Facts
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Brand/Commercial Names
Nicotine

Uses
Thrive lozenges can help you stop smoking by reducing withdrawal symptoms and nicotine cravings. Using Thrive lozenges can enable you to reduce the daily number of cigarettes smoked to ease the transition into a smoke-free lifestyle. Although smoking cessation is preferable, THRIVE lozenges can also be used in cases when you need to temporarily refrain from smoking, for example, in smoke-free areas, airplanes, etc. or in other situations when you wish to avoid smoking. Product effectiveness is directly related to your motivation to stop smoking.

Active Ingredient(s)

Nicotine (as nicotine bitartrade dihydrate)

Chemically and Mechanistically Related Drugs

Nicotex, Nicorette, Nicoderm, Nicogum, Nicotinell, Thrive and Commit Lozenge

Pediatric Use
Do not give this medication to anyone under 18 years old without medical advice.

Use in the Elderly
In elderly patients, failure to thrive describes a state of decline that is multifactorial and may be caused by chronic concurrent diseases and functional impairments. Manifestations of this condition include weight loss, decreased appetite, poor nutrition, and inactivity. Four syndromes are prevalent and predictive of adverse outcomes in patients with failure to thrive: impaired physical function, malnutrition, depression, and cognitive impairment.

Interesting Fact(s)
Thrive® Lozenges dissolve quickly in your mouth, releasing controlled amounts of nicotine into your body for relief of your cravings and withdrawal symptoms. One lozenge should be placed in the mouth and allowed to dissolve. Move the lozenge occasionally from one side of the mouth to the other. Repeat until the lozenge is completely dissolved (about 10 minutes).
The Nicotine transdermal patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging). Remove the patch before undergoing such a test.

Nicotine as Therapy
There’s a cheap, common, and mostly safe drug, in daily use for centuries by hundreds of millions of people that only lately has been investigated for its therapeutic potential for a long list of common ills. The list includes Alzheimer disease, Parkinson disease, depression and anxiety, schizophrenia, attention deficit hyperactivity disorder (ADHD), and even pain and obesity. Why has interest in this potential cure-all been slow to develop? One reason: in its current forms the drug offers pharmaceutical companies no possibility of substantial profit. Another, perhaps more important: the drug is reviled as the world’s most addictive.
Nicotine is an alkaloid in the tobacco plant Nicotiana tabacum, which was smoked or chewed in the Americas for thousands of years before European invaders also succumbed to its pleasures and shipped it back to the Old World.

Nicotine and the Brain
People with depressive-spectrum disorders, schizophrenia, and adult ADHD tend to smoke heavily, which suggested to researchers that nicotine may soothe their symptoms. Common to all these disorders is a failure of attention, an inability to concentrate. Nicotine helps.
Smokers also have lower rates of neurodegenerative disorders, and nicotine improves cognitive and motor functioning in people with Alzheimer disease and Parkinson disease.
Some researchers is heading the first study ever to examine the efficacy and safety of nicotine patches for treating mild cognitive impairment, thought to be a precursor of Alzheimer disease. The researchers hope to see a positive effect on attention and learning. They also heads two studies of nicotinic stimulation in ADHD, using the patch, nicotine blockers, and some novel drugs that activate nicotine receptors.

Nicotine and Pain
Two much newer topics of academic research are nicotine’s potential for pain relief and for treating obesity. Nicotine itself has provided modest pain relief in animal studies.
Meanwhile, nicotine is also being investigated as an analgesic in humans.
The nice thing about nicotine and drugs like nicotine is that they have opposite side effects to anesthetics. Instead of being respiratory depressants, they are respiratory stimulants. Instead of being sedating, they increase alertness.

Nicotine and Weight Gain
Nicotine may be the most effective drug around for weight control. As ex-smokers know, to their rue, one of the worst things about quitting cigarettes is putting on pounds—as much as 10% of body weight.
Ming Li and his colleagues at the University of Texas in San Antonio, Texas, are studying nicotine’s effects on weight. In the weight study, nicotine-treated rats not only lost weight, they lost about 20% of their body fat compared to saline-treated controls. The researchers suggest that, among its other effects, nicotine alters fat storage.

Nicotine’s Future
Developing new drugs that selectively target specific subtypes of nicotine receptors is an expensive proposition. And therein lies a question. Will nicotine-based therapy consist mostly of costly new drugs from the pharmaceutical industry? Or can less expensive nicotine products like the patch, chewing gum, and nasal spray—which are generally intended for smoking cessation but widely available, usually without prescription—find their way into the world’s medicine cabinets?
Yet much of the work to date showing nicotine’s effectiveness on a huge range of disorders has involved products available at any drugstore and intended to help people quit smoking. Newhouse is using patches for mild cognitive impairment. Flood has demonstrated pain relief with nasal spray and will use patches in her next study. And Role feels that gum hasn’t been adequately explored for its therapeutic potential. Nicotine gum, she notes, is a better imitator of smoking than the patch because it delivers brief hits rather than a steady supply. But Role also points out that nicotine has its serious problems—addictive potential, cardiovascular damage, and (especially when delivered through the mucosa) cancer.

Posted in Side Effects

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