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Epipen Medical Research Studies

Up-to-date List of Epipen Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Epipen Medical Research Studies

Rank Status Study
1 Unknown  Trial of Vasopressin and Epinephrine to Epinephrine Only for In-Hospital Pediatric Cardiopulmonary Resuscitation
Conditions: Cardiopulmonary Arrest;   Cardiac Arrest
Interventions: Drug: Vasopressin;   Drug: Epinephrine
Outcome Measures: Combination vasopressin and epinephrine (CPA refractory to cardiopulmonary resuscitation and initial epinephrine dosing) will increase the proportion of patients surviving to hospital discharge by 25% compared to epinephrine alone.;   Combination vasopressin and epinephrine will decrease the time to ROSC;   Vasopressin and epinephrine will improve the proportion of CPA survivors with favorable neurologic outcome (short-term Pediatric Overall Performance Category) [POPC] score discharge of 1-3 or unchanged from hospital admission at the time of hospital .;   Vasopressin and epinephrine will improve the proportion of CPA survivors with favorable neurologic outcome (short-term Pediatric Cerebral Performance Category) [PCPC] score of 1-3 or unchanged from hospital admission at time of hospital discharge.;   Combination vasopressin and epinephrine will improve 24 hour survival.;   Combination vasopressin and epinephrine will decrease the proportion of patients who require prolonged CPR (CPR > 20minutes) to achieve sustained ROSC.;   Combination vasopressin and epinephrine will increase organ recovery in those patients who meet brain death criteria following the CPA event.;   Combination epinephrine and vasopressin will improve rates of return of spontaneous circulation (ROSC)
2 Not yet recruiting The Effect and Safety of Low Dose Nebulized Epinephrine in Croup
Conditions: Croup;   Epinephrine Neublizer Treatment
Interventions: Drug: conventional dose epinephrine;   Drug: low dose epinephrine
Outcome Measures: the difference of Westley croup score between baseline and 30 minutes after neublized treatment;   the incidence of use of additional neublized treatment;   Westley croup score;   the side effect of epinephrine;   respiratory rate, oxygen saturation;   health care utilization- length of stay in emergency department, admission rate, revisit dut to croup symptom;   treatment failure;   rebound effect
3 Unknown  Intranasal Injection Versus Topical Administration of Epinephrin During Endoscopic Sinus Surgery
Conditions: Hypertension;   Hypotension;   Tachycardia;   Bradycardia;   Arrhythmia
Interventions: Drug: Epinephrin (Intranasal injection);   Drug: Epinephrin (Topical administration)
Outcome Measures: Intraoperative hemodynamic alterations (instability);   Hemostasis
4 Unknown  Low-Dose Epinephrine Infusion Tests in Adolescent and Pediatric Patients
Condition: Congenital Disorders
Intervention: Drug: Epinephrine
Outcome Measures: The primary aim of this study is to document that normal healthy pediatric subjects will not prolong their QT interval when subjected to low-dose epinephrine infusion.;   As a secondary aim, to quantitate inter-observer variability when measuring QT intervals during an epinephrine infusion stress test in the pediatric population
5 Recruiting Evaluation of Molecular Markers in Adrenal Tumors
Condition: Adrenal Gland Neoplasms
Outcome Measures: To evaluate the feasibility of molecular testing in adrenal neoplasm FNA biopsy samples.;   To determine the accuracy of novel diagnostic molecular markers in clinical adrenal FNA biopsy and surgically resected samples.;   To analyze the gene expression level relative to disease-free survival and overall survival in patients with adrenocortical carcinoma.
6 Not yet recruiting Combined FDG-PET and 123I-Iodometomidate Imaging for Adrenal Neoplasia
Condition: Adrenal Gland Neoplasms
Interventions: Other: FDG positron emission tomography;   Other: Iodometomidate imaging
Outcome Measures: Specificity of combined FDG-PET and 123I-IMTO imaging for diagnosing adrenocortical adenoma;   Sensitivity of combined FDG-PET and 123I-IMTO imaging for diagnosing adrenocortical adenoma
7 Recruiting Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyperplasia
Conditions: Adrenal Insufficiency;   Excess Androgen;   Congenital Adrenal Hyperplasia (CAH)
Interventions: Drug: Hydrocortisone (Solucortef);   Device: Insulin pump (Medtronic)
Outcome Measures: Percent of patients with 17-OH Progesterone levels equal or below 1,200 ng/dL at 8 a.m.;   Percent of patients with hypertensive BP measurements;   Body composition measured by DEXA;   Weight and BMI;   Insulin resistance measured by HOMA-IR;   Change in percent of patients with androstenedione & amp; testosterone within the normal range at 8 a.m.;   Fatigue and quality of life.
8 Recruiting Efficacy of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic Thyroidectomy
Conditions: Thyroid Neoplasm;   Goiter
Intervention: Drug: Ropivacaine with epinephrine injection
Outcome Measures: Change of VAS pain scores for the first 12 hours;   Maximum of measured systolic blood pressures;   Maximum of measured diastolic blood pressures;   Maximum of measured heart rates;   Blood loss amount
9 Unknown  The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery
Condition: Chronic Sinusitis
Interventions: Drug: 1% lidocaine with 1:100,000 adrenaline;   Drug: 1% lidocaine with 1:200,000 adrenaline
Outcome Measures: Reduction of Intraoperative bleeding;   hemodynamic fluctuation
10 Recruiting Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism
Condition: Primary Aldosteronism
Intervention: Drug: Synacthen infusion during adrenal venous sampling
Outcome Measure: To verify whether Synacthen infusion may influence the results of adrenal venous sampling in patients with primary aldosteronism
11 Recruiting Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation
Condition: Asthma
Interventions: Drug: IM epinephrine 1:1000;   Other: No intervention
Outcome Measures: Change in percent of predicted Peak Expiratory Flow Rate (PEFR) or clinical asthma score 15 minutes after the study intervention (t15).;   1. Change in percent of predicted PEFR/CAS at t15;   2. Disposition;   3. Change in percent of predicted PEFR/CAS at t30, t60, t90 and t120;   4. Change in percent of predicted PEFR/CAS at t30, t60, t90 and t120;   5. Change in respiratory rate at t15, t30, t60, t90 and t120;   6. Change in heart rate at t15, t30, t60, t90 and t120;   7. Need for supplemental oxygen at t60, t90 and t120 (defined as a room air pulse oximetry of <93%);   8. Need for albuterol at t60, t90 and t120;   9. Number of hours of albuterol therapy in the emergency department;   10. ED length of stay
12 Not yet recruiting Effect of Dexamethasone and Epinephrine on the Duration of Sciatic Nerve Blocks With Ropivacaine
Condition: Postoperative Pain
Interventions: Drug: Dexamethasone;   Drug: Epinephrine
Outcome Measures: time to first analgesic request after postanesthetic care unit discharge;   time of recovery of motor and sensory functions on the operated foot
13 Recruiting A European Post-Authorisation Observational Study (Registry) of Patients With Chronic Adrenal Insufficiency
Condition: Chronic Adrenal Insufficiency
Outcome Measures: Incidence of intercurrent illness;   Incidence of adrenal crisis;   Incidence of serious adverse events
14 Recruiting Vasopressin Versus Epinephrine in Myomectomy
Condition: Uterine Myomas
Interventions: Drug: Epinephrine;   Drug: Vasopressin
Outcome Measure: Operative blood loss
15 Unknown  Performance of 18F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in the Diagnosis of Indeterminate Adrenal Tumors on Conventional Imaging: A French Prospective Multicentric Study
Condition: Adrenal Gland Neoplasms
Intervention: Other: FDG-PET scan
Outcome Measures: diagnostic accuracy of FDG-PETparticularly the SUVmax tumor/liver ratio, in the diagnosis of indeterminate adrenal tumors on conventional imaging.;   assess the diagnostic accuracy of the tumorSUVmax, and SUVmax of the tumor/mean SUV of the liver.;   To evaluate the relationship between SUVmax tumor/liver ratio and Weiss score;   To evaluate the impact of the use of FDG-PET on the treatment options;   To evaluate the economic impact of FDG-PET in the management of indeterminate adrenal tumors (ancillary study).
16 Recruiting Prevalence Study of Adrenal Suppression After Corticosteroids During Chemotherapy.
Condition: Adrenal Suppression
Intervention: Other: Prevalence study only, no study intervention
Outcome Measure:
17 Recruiting Adrenal Hyperplasia Among Young People With PCOS
Conditions: Adrenal Hyperplasia;   Polycystic Ovarian Syndrome;   Oligomenorrhea;   Obesity;   Hyperandrogenism
Outcome Measure:
18 Recruiting Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery
Condition: Chronic Sinusitis
Interventions: Drug: Cocaine;   Drug: Adrenaline
Outcome Measures: to estimate the change in bleeding category (surgical field improvement) as measured on a six-point scale, measured from 0 (best case) to 5 (worst case).;   Heart rate;   Blood pressure;   End tidal CO2
19 Recruiting Epinephrine, Dexamethasone, and Hypertonic Saline in Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety
Condition: Bronchiolitis
Interventions: Drug: Epinephrine and Dexamethasone;   Drug: Hypertonic Saline;   Drug: Normal Saline
Outcome Measures: Rate of hospital admissions at seven day in infants whit bronchiolitis.;   Number of participants with adverse events in each arm of treatment
20 Unknown  Adrenal Insufficiency in Critical Emergencies in Digestive Diseases
Conditions: Digestive Diseases;   Adrenal Insufficiency;   Gastrointestinal Bleeding;   Variceal Bleeding;   Acute Pancreatitis
Outcome Measures: Relative adrenal insufficiency;   Therapeutic failure;   Survival;   Variations in portal hypertension.;   Need for vasopressive drugs

These studies may lead to new treatments and are adding insight into Epipen etiology and treatment.

A major focus of Epipen research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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