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Tiredness (76)
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Sweats (26)
Pancreatitis (21)
Body Aches (21)
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Cymbalta Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 12903 

Vomiting, Headache, Nausea, Withdrawal Syndrome, Migraine, Paraesthesia (8473515-7)
on Jun 22, 2012 Female from UNITED STATES , weighting 160.0 lb, was diagnosed with
  • complex regional pain syndrome
  • depression
and was treated with Cymbalta. Directly after, patient experienced the unwanted or unexpected Cymbalta side effects: vomiting, headache, nausea, withdrawal syndrome, migraine, paraesthesia. Cymbalta dosage: 30 Mg 1 Daily Po.

Fatigue, Chest Discomfort, Blood Pressure Increased (8470727-3)
Patient was taking Cymbalta. Patient felt the following Cymbalta side effects: fatigue, chest discomfort, blood pressure increased on Jun 25, 2012 from UNITED STATES Additional patient health information: Female , weighting 185.0 lb, was diagnosed with
  • depression
  • contraception
  • multiple sclerosis
  • hypersensitivity
and. Cymbalta dosage: 1 Df, Daily.
Multiple prescriptions taken:
  • Seasonale (1 Df, Daily)
  • Gilenya (0.5 Mg, Qd)
  • Zyrtec (1 Df, Daily)


Confusional State, Dysarthria, Pain, Abnormal Behaviour, Oedema Peripheral (8470195-1)
Adverse event was reported on Jun 21, 2012 by a Female taking Cymbalta (Dosage: 30 Mg, Daily, Po) was diagnosed with
  • back pain
and. Location: UNITED STATES , 26 years of age, weighting 135.0 lb, After Cymbalta was administered, patient encountered several Cymbalta side effects: confusional state, dysarthria, pain, abnormal behaviour, oedema peripheral. Patient was hospitalized.

Mouth Haemorrhage, Suicidal Ideation, Gastric Ulcer, Withdrawal Syndrome, Stress, Depression, Crying, Stomatitis, Oral Pain (8469813-3)
on Jun 13, 2012 Female from UNITED STATES , 69 years of age, was diagnosed with
  • depression
and was treated with Cymbalta. Directly after, patient experienced the unwanted or unexpected Cymbalta side effects: mouth haemorrhage, suicidal ideation, gastric ulcer, withdrawal syndrome, stress, depression, crying, stomatitis, oral pain. Cymbalta dosage: 30 Mg, Qd.


Abdominal Distension, Depression, Bile Duct Stone, Gastritis, Candidiasis, Asthenia, Urinary Tract Infection, Synovitis, Spinal Disorder (8469802-9)
on Jun 19, 2012 Female from UNITED STATES , 58 years of age, was treated with Cymbalta. Patient felt the following Cymbalta side effects: abdominal distension, depression, bile duct stone, gastritis, candidiasis, asthenia, urinary tract infection, synovitis, spinal disorder. Cymbalta dosage: N/A.
Multiple prescriptions taken:
  • Os-cal (calcium Carbonate)
  • Prednisone
  • Remicade
  • Methotrexate Sodium
Patient was hospitalized.

Sepsis, Humerus Fracture, Dyspnoea, Small Intestinal Obstruction, Urinary Retention, Tendon Rupture (8469580-3)
Patient was taking Cymbalta. After Cymbalta was administered, patient encountered several Cymbalta side effects: sepsis, humerus fracture, dyspnoea, small intestinal obstruction, urinary retention, tendon rupture on Jun 18, 2012 from UNITED STATES Additional patient health information: Male , weighting 150.0 lb, . Cymbalta dosage: 40 Mg, Qd.
Multiple concurrent drugs taken:
  • Percocet (Unk)
  • Wellbutrin (300 Mg, Qd)
  • Advair Diskus 100/50 (Unk)
  • Centrum Silver /01292501/ (1 Unk, Qd)
  • Clonazepam (0.5 Mg, Qd)
  • Calcium With Vitamin D /00944201/ (Unk)
  • Nexium (40 Mg, Qd)
  • Aspirin (325 Mg, Qd)
Patient was hospitalized.

Mouth Ulceration, Pain (8467013-4)
Adverse event was reported on Jun 25, 2012 by a Female taking Cymbalta (Dosage: 90 Mg, 1 X Day, Inj) was diagnosed with
  • depression
  • pain
and. Location: UNITED STATES , 51 years of age, weighting 110.0 lb, Directly after, patient experienced the unwanted or unexpected Cymbalta side effects: mouth ulceration, pain.

Muscle Spasms (8466750-5)
on Jun 21, 2012 Male from UNITED STATES , weighting 197.0 lb, was diagnosed with
  • hypertension
  • blood cholesterol increased
  • heart rate increased
and was treated with Cymbalta. Patient felt the following Cymbalta side effects: muscle spasms. Cymbalta dosage: 60 Mg, Daily.
Multiple prescriptions taken:
  • Lipitor (40 Mg, Unk)
  • Metoprolol (25 Mg, 2x/day)
  • Lipitor (20 Mg, Daily)


Obsessive Thoughts, Lethargy, Nightmare, Paranoia, Confusional State, Psychotic Disorder, Quality Of Life Decreased, Anger, Hostility (8466490-2)
on Jun 20, 2012 Female from UNITED STATES , 63 years of age, weighting 145.0 lb, was diagnosed with
  • nervous system disorder
and was treated with Cymbalta. After Cymbalta was administered, patient encountered several Cymbalta side effects: obsessive thoughts, lethargy, nightmare, paranoia, confusional state, psychotic disorder, quality of life decreased, anger, hostility. Cymbalta dosage: 1 Capsule Nightly Po. Patient was hospitalized.

Bone Density Decreased, Pain, Stress Fracture, Hip Fracture, Rib Fracture, Osteopenia (8465075-1)
Patient was taking Cymbalta. Directly after, patient experienced the unwanted or unexpected Cymbalta side effects: bone density decreased, pain, stress fracture, hip fracture, rib fracture, osteopenia on Jun 19, 2012 from UNITED STATES Additional patient health information: Female , 49 years of age, weighting 182.1 lb, . Cymbalta dosage: N/A.
Associated medications used:
  • Estradiol Norethindrone (1.0 To 0.5 Mg One Po Qd)
  • Celexa
  • Medrol
  • Zoloft
  • Naprosyn Sodium (550 Mg One Po Bid Prn With Food 7 To 10 D As Needed)
  • Butal/apap/caff Plus
  • Robaxin (750 Mg Tablet 1 Po Tid Prn)
  • Nexium
Patient was hospitalized.

Mental Disorder, Suicide Attempt, Feeling Abnormal, Intentional Overdose, Irritability, Fatigue, Disturbance In Attention, Depressed Mood (8464612-0)
Adverse event was reported on Jun 20, 2012 by a Male taking Cymbalta (Dosage: 30mg Once Daily Oral ; 60mg Once Daily Oral) was diagnosed with
  • arthralgia
  • fibromyalgia
and. Location: UNITED STATES , 52 years of age, weighting 180.3 lb, Patient felt the following Cymbalta side effects: mental disorder, suicide attempt, feeling abnormal, intentional overdose, irritability, fatigue, disturbance in attention, depressed mood. Patient was hospitalized.

Pneumonia (8464534-5)
on Nov 29, 2011 Female from UNITED STATES , 62 years of age, was treated with Cymbalta. After Cymbalta was administered, patient encountered several Cymbalta side effects: pneumonia. Cymbalta dosage: N/A.
Multiple concurrent drugs taken:
  • Prilosec
  • Acyclovir
  • Erythromycin
  • Levothyroxine Sodium
  • Morphine
  • Prednisone Tab
  • Bromelain (bromelains)
  • Ativan


Insomnia, Paraesthesia, Dizziness, Impaired Driving Ability, Palpitations, Dysstasia, Activities Of Daily Living Impaired, Mood Swings, Respiratory Disorder (8462659-1)
on Jun 19, 2012 Female from UNITED STATES , 27 years of age, weighting 250.0 lb, was diagnosed with
  • depression
  • back pain
  • anxiety
and was treated with Cymbalta. Directly after, patient experienced the unwanted or unexpected Cymbalta side effects: insomnia, paraesthesia, dizziness, impaired driving ability, palpitations, dysstasia, activities of daily living impaired, mood swings, respiratory disorder. Cymbalta dosage: 60mg Qd Po.

Product Quality Issue, Nightmare, Insomnia, Product Substitution Issue (8462588-3)
Patient was taking Cymbalta. Patient felt the following Cymbalta side effects: product quality issue, nightmare, insomnia, product substitution issue on Jun 20, 2012 from UNITED STATES Additional patient health information: Female , weighting 140.2 lb, . Cymbalta dosage: N/A.
Multiple prescriptions taken:
  • Zolpidem (Zolpidem 10 Mg Nightly Po)
  • Hydromorphone Hcl
  • Zolpidem
  • Oxycodone Hcl And Acetaminophen
  • Diazepam


Abasia, Pain, Hospitalisation, Dementia, Oedema Peripheral, Feeling Abnormal (8458866-4)
Adverse event was reported on Jun 12, 2012 by a Female taking Cymbalta (Dosage: N/A) was diagnosed with
  • fibromyalgia
and. Location: UNITED STATES , 72 years of age, After Cymbalta was administered, patient encountered several Cymbalta side effects: abasia, pain, hospitalisation, dementia, oedema peripheral, feeling abnormal.
Multiple concurrent drugs taken:
  • Seroquel
  • Risperidone
Patient was hospitalized.

Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Off Label Use (8458865-2)
on Jun 11, 2012 Male from FRANCE , 65 years of age, weighting 138.9 lb, was diagnosed with
  • urinary incontinence
  • hypertension
and was treated with Cymbalta. Directly after, patient experienced the unwanted or unexpected Cymbalta side effects: alanine aminotransferase increased, aspartate aminotransferase increased, off label use. Cymbalta dosage: N/A.
Associated medications used:
  • Losartan Potassium And Hydrochlorothiazide (Unk)


Erythema, Skin Exfoliation (8458847-0)
on Jun 11, 2012 Female from UNITED STATES , 60 years of age, was diagnosed with
  • depression
and was treated with Cymbalta. Patient felt the following Cymbalta side effects: erythema, skin exfoliation. Cymbalta dosage: N/A.

Product Quality Issue, Product Adhesion Issue, Application Site Pruritus, Skin Irritation, Upper Limb Fracture, Convulsion (8458202-3)
Patient was taking Cymbalta. After Cymbalta was administered, patient encountered several Cymbalta side effects: product quality issue, product adhesion issue, application site pruritus, skin irritation, upper limb fracture, convulsion on Jun 14, 2012 from UNITED STATES Additional patient health information: Female , weighting 190.0 lb, was diagnosed with
  • depression
and. Cymbalta dosage: N/A.
Multiple concurrent drugs taken:
  • Multi-vitamins
  • Tramadol Hcl (For 1 Month)


Pain, Condition Aggravated, Arthralgia, Hyperhidrosis, Myalgia, Tremor, Somnolence, Impaired Work Ability, Mental Impairment (8457711-0)
Adverse event was reported on Jun 18, 2012 by a Male taking Cymbalta (Dosage: 30mg 4x A Day Po) was diagnosed with
  • major depression
and. Location: UNITED STATES , 45 years of age, weighting 228.0 lb, Directly after, patient experienced the unwanted or unexpected Cymbalta side effects: pain, condition aggravated, arthralgia, hyperhidrosis, myalgia, tremor, somnolence, impaired work ability, mental impairment.

Hyperhidrosis, Nausea, Vomiting, Hot Flush, Bedridden, Paraesthesia, Night Sweats, Activities Of Daily Living Impaired (8457686-4)
on Jun 18, 2012 Female from UNITED STATES , 30 years of age, weighting 125.0 lb, was diagnosed with
  • depression
  • anxiety
and was treated with Cymbalta. Patient felt the following Cymbalta side effects: hyperhidrosis, nausea, vomiting, hot flush, bedridden, paraesthesia, night sweats, activities of daily living impaired. Cymbalta dosage: 60 Mg Daily Buccal.

Infection (8456169-5)
on Aug 24, 2011 Female from UNITED STATES , 51 years of age, was treated with Cymbalta. After Cymbalta was administered, patient encountered several Cymbalta side effects: infection. Cymbalta dosage: N/A.
Multiple concurrent drugs taken:
  • Hydromorphone Hcl
  • Lantus
  • Metfformin Hydrochloride
  • Levothyroxine Sodium
  • Alprazolam
  • Velcade
  • Dexamethasone (dexamethasone)
  • Lovenox
Patient was hospitalized.

Breast Cancer Female (8455522-3)
Patient was taking Cymbalta. Directly after, patient experienced the unwanted or unexpected Cymbalta side effects: breast cancer female on Jun 14, 2012 from UNITED STATES Additional patient health information: Female , weighting 149.9 lb, was diagnosed with
  • fibromyalgia
  • thyroid disorder
and. Cymbalta dosage: 60 Mg, 1x/day.
Associated medications used:
  • Synthroid (100 Ug, 1x/day)
  • Lyrica (75 Mg, 4x/day)
Patient was hospitalized.

Diarrhoea, Vomiting, Nausea (8451544-7)
Adverse event was reported on May 14, 2012 by a Male taking Cymbalta (Dosage: N/A) was diagnosed with
  • depression
  • hepatitis c
and. Location: , weighting 150.1 lb, Patient felt the following Cymbalta side effects: diarrhoea, vomiting, nausea.
Multiple prescriptions taken:
  • Incivek
  • Pegasys
  • Ribavirin


Rectal Haemorrhage, Haemorrhoids, Rash Papular, Rash Pruritic, Proctalgia, Pruritus (8451202-9)
on Mar 05, 2012 Male from UNITED STATES , weighting 190.2 lb, was treated with Cymbalta. After Cymbalta was administered, patient encountered several Cymbalta side effects: rectal haemorrhage, haemorrhoids, rash papular, rash pruritic, proctalgia, pruritus. Cymbalta dosage: N/A.
Multiple concurrent drugs taken:
  • Pegasys
  • Incivek
  • Gabapentin
  • Acetaminophen
  • Ribavirin
  • Sleeping Pill
  • Claritin
  • Remeron


Urticaria, Skin Exfoliation, Rash Pruritic, Sleep Disorder, Scar, Erythema (8450278-2)
on Jun 14, 2012 Patient from UNITED STATES , weighting 162.0 lb, was diagnosed with
  • menopausal symptoms
and was treated with Cymbalta. Directly after, patient experienced the unwanted or unexpected Cymbalta side effects: urticaria, skin exfoliation, rash pruritic, sleep disorder, scar, erythema. Cymbalta dosage: 30 Mg, 1xdaily.

Showing 1-25 of 12903 

Cymbalta Health Episodes

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Record and Track Your Side Effects

It is very important to keep track of all side effects and discuss them with your doctor. If you think you may have a medical emergency, call your doctor or 911 immediately.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Cymbalta Information

Alternative CYMBALTA Names:DULOXETIN

Active Ingredient: DULOXETIN

Cymbalta Dosage, Warnings, Usage.

Side Effects reported to FDA: 12903. View Cymbalta Adverse Reports

Cymbalta safety alerts: 2005

Reported deaths: 747

Reported hospitalizations: 3368

Cymbalta (duloxetine) Public Health Advisory: Suicidality in Adults Being Treated with Antidepressant Medications

Audience: Neuropsychiatric healthcare professionals and consumers

[UPDATE 07/08/2005] FDA notified healthcare professionals about the availability of updated Healthcare Professional and Patient Information Sheets for antidepressant medications that were the subject of a June 30, 2005 Public Health Advisory issued about the risk of suicidality (suicidal thinking or behavior) in adults being treated with antidepressant medications.

[Posted 07/01/2005] In response to recent scientific publications that report the possibility of increased risk of suicidal behavior in adults treated with antidepressants, the FDA has issued a Public Health Advisory to update patients and healthcare providers with the latest information on this subject. Even before the publication of these recent reports, FDA had already begun the process of reviewing available data to determine whether there is an increased risk of suicidal behavior in adults taking antidepressants. The Agency has asked manufacturers to provide information from their trials using an approach similar to that used in the evaluation of the risk of suicidal behavior in the pediatric population taking antidepressants. This effort will involve hundreds of clinical trials and may take more than a year to complete.

[July 08, 2005 - Healthcare Professional and Patient Information Sheets - FDA]
[June 30, 2005 - Public Health Advisory - FDA]
[June 30, 2005 - Drug Information Page - FDA]

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