Common Fosamax Side Effects


The most commonly reported Fosamax side effects (click to view or check a box to report):

Femur Fracture (5674)
Anxiety (3177)
Osteonecrosis (2820)
Fall (2638)
Depression (2384)
Arthralgia (1887)
Dental Caries (1634)
Arthropathy (1621)
Back Pain (1566)
Low Turnover Osteopathy (1355)
Anaemia (1283)
Osteomyelitis (1270)
Hypertension (1242)
Blood Cholesterol Increased (1236)
Impaired Healing (1123)
Abscess (1121)
Adverse Event (1103)
Bone Density Decreased (1051)
Bone Disorder (1048)
Chest Pain (1022)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Fosamax Side Effects Reported to FDA



Fosamax Side Effect Report#9994571
Alanine Aminotransferase Increased, Blood Glucose Increased
This is a report of a 69-year-old female patient (weight: NA) from CA, suffering from the following health symptoms/conditions: NA, who was treated with Fosamax (dosage: 70 Mg, Qw, start time: NS), combined with:
  • Aclasta (5.0 Mg, Once A Year)
  • Aclasta (5 Mg, Unk)
and developed a serious reaction and side effect(s): Alanine Aminotransferase Increased, Blood Glucose Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Fosamax treatment in female patients, resulting in Alanine Aminotransferase Increased side effect.
Fosamax Side Effect Report#9994183
Stress Fracture, Atypical Femur Fracture
This report suggests a potential Fosamax Stress Fracture side effect(s) that can have serious consequences. A 74-year-old female patient (weight: NA) from CA was diagnosed with the following symptoms/conditions: NA and used Fosamax (dosage: NA) starting NS. After starting Fosamax the patient began experiencing various side effects, including: Stress Fracture, Atypical Femur FractureAdditional drugs used concurrently:
  • Fosavance
The patient was hospitalized. Although Fosamax demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Stress Fracture, may still occur.
Fosamax Side Effect Report#9994172
Fall, Femur Fracture
This Fall problem was reported by a physician from CA. A 75-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Fosamax (dosage: 70 Mg, Qw). The following drugs were being taken at the same time:
  • Gabapentin
  • Hydroxychloroquine Sulfate
  • Levothyroxine Sodium
When using Fosamax, the patient experienced the following unwanted symptoms/side effects: Fall, Femur FractureThe patient was hospitalized and became disabled.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Fall, may become evident only after a product is in use by the general population.
Fosamax Side Effect Report#9994143
Fall, Atypical Femur Fracture
This Fall side effect was reported by a physician from CA. A 71-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Fosamax (drug dosage: 70 Mg, Qw), which was initiated on NS. Concurrently used drugs:
  • Amlodipine
  • Aspirin
  • Calcium Carbonate
  • Candesartan Cilexetil
  • Celebrex
  • Clonazepam
  • Metoprolol
  • Mirtazapine
.After starting to take Fosamax the consumer reported adverse symptoms, such as: Fall, Atypical Femur FractureThese side effects may potentially be related to Fosamax. The patient was hospitalized and became disabled.
Fosamax Side Effect Report#9988228
Dental Operation, Tooth Extraction
This is a report of a 66-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: osteoporosis, who was treated with Fosamax (dosage: 70 Mg, Once Weekly, start time:
Feb 22, 2014), combined with:
  • Omeprazole (20 Mg, Once Daily)
and developed a serious reaction and side effect(s): Dental Operation, Tooth Extraction after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Fosamax treatment in female patients, resulting in Dental Operation side effect.
Fosamax Side Effect Report#9988216
Adverse Event, Tooth Abscess, Dental Caries, Rheumatoid Arthritis
This report suggests a potential Fosamax Adverse Event side effect(s) that can have serious consequences. A 58-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: osteoporosis and used Fosamax (dosage: 70 Mg, Qw) starting 200902. After starting Fosamax the patient began experiencing various side effects, including: Adverse Event, Tooth Abscess, Dental Caries, Rheumatoid ArthritisAdditional drugs used concurrently: NA. Although Fosamax demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Adverse Event, may still occur.
Fosamax Side Effect Report#9988151
Clostridium Difficile Infection, Osteomyelitis, Tibia Fracture, Tibia Fracture
This Clostridium Difficile Infection problem was reported by a physician from CA. A 59-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Fosamax (dosage: Unk). The following drugs were being taken at the same time:
  • Carbocal D
  • Lescol
  • Maxalt
  • Pantoloc
When using Fosamax, the patient experienced the following unwanted symptoms/side effects: Clostridium Difficile Infection, Osteomyelitis, Tibia Fracture, Tibia FractureThe patient was hospitalized and became disabled.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Clostridium Difficile Infection, may become evident only after a product is in use by the general population.
Fosamax Side Effect Report#9985724
Somnolence, Bone Disorder, Decreased Appetite, Asthenia
This Somnolence side effect was reported by a consumer or non-health professional from US. A 78-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Fosamax (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Evista
  • Calcitonin (Unk)
.After starting to take Fosamax the consumer reported adverse symptoms, such as: Somnolence, Bone Disorder, Decreased Appetite, AstheniaThese side effects may potentially be related to Fosamax.
Fosamax Side Effect Report#9985512
Femur Fracture, Osteoporosis, Low Turnover Osteopathy, Burns Second Degree, Cartilage Injury, Femur Fracture, Osteoarthritis, Fall, Foot Fracture
This is a report of a female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Fosamax (dosage: NA, start time: 1974), combined with: NA. and developed a serious reaction and side effect(s): Femur Fracture, Osteoporosis, Low Turnover Osteopathy, Burns Second Degree, Cartilage Injury, Femur Fracture, Osteoarthritis, Fall, Foot Fracture after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Fosamax treatment in female patients, resulting in Femur Fracture side effect. The patient was hospitalized and became disabled.
Fosamax Side Effect Report#9981215
Musculoskeletal Chest Pain, Spinal Pain, Arthralgia
This report suggests a potential Fosamax Musculoskeletal Chest Pain side effect(s) that can have serious consequences. A 49-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: osteoporosis and used Fosamax (dosage: NA) starting
Mar 01, 2014. After starting Fosamax the patient began experiencing various side effects, including: Musculoskeletal Chest Pain, Spinal Pain, ArthralgiaAdditional drugs used concurrently: NA. Although Fosamax demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Musculoskeletal Chest Pain, may still occur.
Fosamax Side Effect Report#9971540
Atypical Femur Fracture
This Atypical Femur Fracture problem was reported by a consumer or non-health professional from US. A 63-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: bone densitometry,osteopenia. On NS this consumer started treatment with Fosamax (dosage: 1 Pill). The following drugs were being taken at the same time: NA. When using Fosamax, the patient experienced the following unwanted symptoms/side effects: Atypical Femur FractureThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Atypical Femur Fracture, may become evident only after a product is in use by the general population.
Fosamax Side Effect Report#9969434
Oesophageal Carcinoma
This Oesophageal Carcinoma side effect was reported by a consumer or non-health professional from US. A 58-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Fosamax (drug dosage: Unk), which was initiated on NS. Concurrently used drugs: NA..After starting to take Fosamax the consumer reported adverse symptoms, such as: Oesophageal CarcinomaThese side effects may potentially be related to Fosamax.
Fosamax Side Effect Report#9958643
Femur Fracture, Femur Fracture, Femur Fracture, Internal Fixation Of Fracture, Surgery, Gait Disturbance, Pain
This is a report of a 65-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: osteopenia, who was treated with Fosamax (dosage: 70 Mg, Qw, start time: 2003), combined with:
  • Lipitor
  • Diltiazem Hydrochloride
  • Omeprazole
  • Cozaar
and developed a serious reaction and side effect(s): Femur Fracture, Femur Fracture, Femur Fracture, Internal Fixation Of Fracture, Surgery, Gait Disturbance, Pain after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Fosamax treatment in female patients, resulting in Femur Fracture side effect. The patient was hospitalized and became disabled.
Fosamax Side Effect Report#9937378
Tooth Disorder, Tooth Extraction
This report suggests a potential Fosamax Tooth Disorder side effect(s) that can have serious consequences. A 67-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Fosamax (dosage: Unk) starting NS. After starting Fosamax the patient began experiencing various side effects, including: Tooth Disorder, Tooth ExtractionAdditional drugs used concurrently: NA. Although Fosamax demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Tooth Disorder, may still occur.
Fosamax Side Effect Report#9934168
Femur Fracture, Intramedullary Rod Insertion, Osteoporosis, Stress Fracture, Low Turnover Osteopathy, Pelvic Fracture, Hemiparesis, Asthma, Thyroid Disorder
This Femur Fracture problem was reported by a physician from US. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: osteopenia,osteoporosis. On 200608 this consumer started treatment with Fosamax (dosage: Unk). The following drugs were being taken at the same time: NA. When using Fosamax, the patient experienced the following unwanted symptoms/side effects: Femur Fracture, Intramedullary Rod Insertion, Osteoporosis, Stress Fracture, Low Turnover Osteopathy, Pelvic Fracture, Hemiparesis, Asthma, Thyroid DisorderThe patient was hospitalized and became disabled.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Femur Fracture, may become evident only after a product is in use by the general population.
Fosamax Side Effect Report#9929531
Intramedullary Rod Insertion, Osteoporosis, Low Turnover Osteopathy, Stress Fracture, Femur Fracture, Bone Disorder, Urinary Tract Infection, Pancreatitis Acute, Femur Fracture
This Intramedullary Rod Insertion side effect was reported by a physician from US. A female patient (weight:NA) experienced the following symptoms/conditions: osteopenia.The patient was prescribed Fosamax (drug dosage: 70 Mg, Unk), which was initiated on 2000. Concurrently used drugs:
  • Boniva (150 Mg, Unk)
  • Boniva (150 Mg, Unk)
.After starting to take Fosamax the consumer reported adverse symptoms, such as: Intramedullary Rod Insertion, Osteoporosis, Low Turnover Osteopathy, Stress Fracture, Femur Fracture, Bone Disorder, Urinary Tract Infection, Pancreatitis Acute, Femur FractureThese side effects may potentially be related to Fosamax. The patient was hospitalized and became disabled.
Fosamax Side Effect Report#9929064
Femur Fracture, Open Reduction Of Fracture, Atelectasis, Arteriosclerosis, Cardiomegaly, Lung Infiltration, Radius Fracture, Fall, Aortic Calcification
This is a report of a female patient (weight: NA) from US, suffering from the following health symptoms/conditions: osteoporosis, who was treated with Fosamax (dosage: 70 Mg, Qw, start time:
Jul 14, 2008), combined with: NA. and developed a serious reaction and side effect(s): Femur Fracture, Open Reduction Of Fracture, Atelectasis, Arteriosclerosis, Cardiomegaly, Lung Infiltration, Radius Fracture, Fall, Aortic Calcification after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Fosamax treatment in female patients, resulting in Femur Fracture side effect. The patient was hospitalized.
Fosamax Side Effect Report#9925421
Adverse Event
This report suggests a potential Fosamax Adverse Event side effect(s) that can have serious consequences. A 77-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Fosamax (dosage: NA) starting NS. After starting Fosamax the patient began experiencing various side effects, including: Adverse EventAdditional drugs used concurrently: NA. Although Fosamax demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Adverse Event, may still occur.
Fosamax Side Effect Report#9913186
Femur Fracture, Intramedullary Rod Insertion, Osteolysis, Intramedullary Rod Insertion, Biopsy Bone, Large Intestinal Polypectomy, Cellulitis, Colectomy, Electrocauterisation
This Femur Fracture problem was reported by a physician from US. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: osteopenia,osteoporosis. On 199705 this consumer started treatment with Fosamax (dosage: 10 Mg, Qd). The following drugs were being taken at the same time: NA. When using Fosamax, the patient experienced the following unwanted symptoms/side effects: Femur Fracture, Intramedullary Rod Insertion, Osteolysis, Intramedullary Rod Insertion, Biopsy Bone, Large Intestinal Polypectomy, Cellulitis, Colectomy, ElectrocauterisationThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Femur Fracture, may become evident only after a product is in use by the general population.
Fosamax Side Effect Report#9908547
Femur Fracture, Intramedullary Rod Insertion, Bone Disorder, Skin Graft, Vascular Graft, Joint Arthroplasty, Renal Failure Acute, Breast Cancer
This Femur Fracture side effect was reported by a consumer or non-health professional from US. A female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Fosamax (drug dosage: 70 Mg, Qw), which was initiated on NS. Concurrently used drugs:
  • Alendronate Sodium (70 Mg, Unk)
  • Synthroid (125-300 Microgram, Qd)
.After starting to take Fosamax the consumer reported adverse symptoms, such as: Femur Fracture, Intramedullary Rod Insertion, Bone Disorder, Skin Graft, Vascular Graft, Joint Arthroplasty, Renal Failure Acute, Breast CancerThese side effects may potentially be related to Fosamax. The patient was hospitalized and became disabled.
Fosamax Side Effect Report#9908454
Myalgia, Pain, Dyspepsia, Abdominal Discomfort
This is a report of a 67-year-old female patient (weight: NA) from SG, suffering from the following health symptoms/conditions: NA, who was treated with Fosamax Tab 10 Mg (dosage: Unk, start time:
Feb 25, 2013), combined with: NA. and developed a serious reaction and side effect(s): Myalgia, Pain, Dyspepsia, Abdominal Discomfort after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Fosamax Tab 10 Mg treatment in female patients, resulting in Myalgia side effect.
Fosamax Side Effect Report#9906355
Femur Fracture, Intramedullary Rod Insertion, Femur Fracture, Intramedullary Rod Insertion, Fall, Fracture Delayed Union, Impaired Healing, Hypercholesterolaemia, Hypothyroidism
This report suggests a potential Fosamax Femur Fracture side effect(s) that can have serious consequences. A female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Fosamax (dosage: 70 Mg, Qw) starting 1996. After starting Fosamax the patient began experiencing various side effects, including: Femur Fracture, Intramedullary Rod Insertion, Femur Fracture, Intramedullary Rod Insertion, Fall, Fracture Delayed Union, Impaired Healing, Hypercholesterolaemia, HypothyroidismAdditional drugs used concurrently:
  • Alendronate Sodium
The patient was hospitalized. Although Fosamax demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Femur Fracture, may still occur.
Fosamax Side Effect Report#9899398
Femur Fracture, Intramedullary Rod Insertion, Skin Graft, Arthrodesis, Adenocarcinoma Of Colon, Metastases To Lymph Nodes, Sigmoidectomy, Metastases To Liver, Fall
This Femur Fracture problem was reported by a physician from US. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jul 08, 2008 this consumer started treatment with Fosamax (dosage: 10 Mg, Daily). The following drugs were being taken at the same time: NA. When using Fosamax, the patient experienced the following unwanted symptoms/side effects: Femur Fracture, Intramedullary Rod Insertion, Skin Graft, Arthrodesis, Adenocarcinoma Of Colon, Metastases To Lymph Nodes, Sigmoidectomy, Metastases To Liver, FallThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Femur Fracture, may become evident only after a product is in use by the general population.
Fosamax Side Effect Report#9898048
Femur Fracture, Intramedullary Rod Insertion, Tibia Fracture, Fibula Fracture, Impaired Healing, Functional Gastrointestinal Disorder, Nasopharyngitis, Infection, Weight Decreased
This Femur Fracture side effect was reported by a consumer or non-health professional from US. A female patient (weight:NA) experienced the following symptoms/conditions: osteopenia,osteoporosis.The patient was prescribed Fosamax (drug dosage: 10 Mg, Qd), which was initiated on 2000. Concurrently used drugs: NA..After starting to take Fosamax the consumer reported adverse symptoms, such as: Femur Fracture, Intramedullary Rod Insertion, Tibia Fracture, Fibula Fracture, Impaired Healing, Functional Gastrointestinal Disorder, Nasopharyngitis, Infection, Weight DecreasedThese side effects may potentially be related to Fosamax. The patient was hospitalized.
Fosamax Side Effect Report#9892821
Haematochezia, Haematochezia
This is a report of a 53-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: osteoporosis, who was treated with Fosamax (dosage: 70 Mg, Qw, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Haematochezia, Haematochezia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Fosamax treatment in female patients, resulting in Haematochezia side effect.


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The appearance of Fosamax on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Fosamax Side Effects for Women?

Women Side Effects Reports
Femur Fracture 5469
Anxiety 2939
Osteonecrosis 2538
Fall 2515
Depression 2218
Arthralgia 1785
Arthropathy 1519
Dental Caries 1498
Back Pain 1444
Low Turnover Osteopathy 1315

What are common Fosamax Side Effects for Men?

Men Side Effects Reports
Osteonecrosis 274
Anxiety 238
Femur Fracture 176
Depression 166
Dental Caries 135
Death 134
Back Pain 121
Osteomyelitis 117
Fall 116
Impaired Healing 104

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Fosamax reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Fosamax Safety Alerts, Active Ingredients, Usage Information

    NDC 0006-0031
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name FOSAMAX
    Name alendronate sodium
    Dosage Form TABLET
    Route ORAL
    On market since 19950929
    Labeler Merck Sharp & Dohme Corp.
    Active Ingredient(s) ALENDRONATE SODIUM
    Strength(s) 70
    Unit(s) mg/1
    Pharma Class Bisphosphonate [EPC],Diphosphonates [Chemical/Ingredient]

    Fosamax Dosage, Warnings, Usage.

    Side Effects reported to FDA: 23352

    Fosamax safety alerts: 2008 2007

    Reported deaths: 1317

    Reported hospitalizations: 14785

    Bisphosphonates marketed as Alendronate (Fosamax, Fosamax Plus D)

    Etidronate (Didronel)
    Ibandronate (Boniva)
    Pamidronate (Aredia)
    Risedronate (Actonel, Actonel W/Calcium)
    Tiludronate (Skelid)
    Zoledronic acid (Reclast, Zometa)

    Audience: Geriatricians, gynecologists, orthopedic surgeons, other healthcare professionals
    [Posted 11/12/2008] FDA issued an update to the Agency's review of safety data regarding the potential increased risk of atrial fibrillation in patients treated with a bisphosphonate drug. Bisphosphonates are a class of drugs used primarily to increase bone mass and reduce the risk for fracture in patients with osteoporosis, slow bone turnover in patients with Paget�??s disease of the bone, and to treat bone metastases and lower elevated levels of blood calcium in patients with cancer. FDA reviewed data on 19,687 bisphosphonate-treated patients and 18,358 placebo-treated patients who were followed for 6 months to 3 years. The occurrence of atrial fibrillation was rare within each study, with most studies containing 2 or fewer events. Across all studies, no clear association between overall bisphosphonate exposure and the rate of serious or non-serious atrial fibrillation was observed. Additionally, increasing dose or duration of bisphosphonate therapy was not associated with an increase rate of atrial fibrillation. Healthcare professionals should not alter their prescribing patterns for bisphosphonates and patients should not stop taking their bisphosphonate medication.

    [November 12, 2008 - Update to the October 1, 2007 Early Communication about the Ongoing Safety Review of Bisphosphonates - FDA]

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