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Methotrexate Side Effects summary

Total Methotrexate reports: 1177.
Methotrexate FDA safety alerts: 2005 2006 .
Reported deaths: 289    Reported hospitalizations: 437.
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Comments to date: 1. Page 1 of 1.

saleena   Location unknown	7:23pm on Saturday, December 20th, 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine ag... read more »

Methotrexate Poll Results

Have you experienced Methotrexate side effects?

Yes, Severe	45%
Yes, Mild	32%
Yes, Minor	18%
No	5%

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Recent Questions and Answers about Methotrexate

How does methotrexate inhibit the formation of a cancerous tumor?

Methotrexate Side Effects reported on Patientsville.com

Methotrexate Side Effects Report #SELF3086 -1909-05-12
METHOTREXATE problem was reported on 1909-05-12
Patient reported the following METHOTREXATE side effects:Low Blood SugarRead more

Methotrexate FDA reported side effects and reactions

2008

2007

2006

Methotrexate Side Effects reported to FDA

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Showing 1-40 of 1177 Next >

Methotrexate Side Effects Report #5196704-6
Health Professional from UNITED STATES reported METHOTREXATE problem on Dec 26, 2006. Female patient, child 7 years of age, was diagnosed with juvenile arthritis and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: histoplasmosis. METHOTREXATE dosage: unknown. During the same period patient was treated with NAPROXEN, PREDNISONE. Patient was hospitalized. Patient recovered.



Methotrexate Side Effects Report #5200069-0
METHOTREXATE problem was reported by a Health Professional from NETHERLANDS on Dec 26, 2006. Female patient, 46 years of age, was diagnosed with rheumatoid arthritis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: anaphylactic reaction. METHOTREXATE dosage: unknown. During the same period patient was treated with ETANERCEPT, PREDNISOLONE. Patient recovered.



Methotrexate Side Effects Report #5200916-2
Health Professional from BELGIUM reported METHOTREXATE problem on Jan 02, 2007. Male patient, 66 years of age, was diagnosed with psoriatic arthropathy and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: bone marrow failure, candidiasis, dermatitis exfoliative, hepatosplenomegaly, hepatotoxicity, mouth ulceration, nausea, pyrexia, stomatitis. METHOTREXATE dosage: unknown. During the same period patient was treated with FOLIC ACID. Patient was hospitalized. Patient recovered.



Methotrexate Side Effects Report #5201960-1
METHOTREXATE problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 04, 2007. Male patient, weighting 121.5 lb, was diagnosed with b precursor type acute leukaemia and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: cerebral infarction, dysarthria, gait disturbance, hemiparesis. METHOTREXATE dosage: 14350 MG. During the same period patient was treated with VINCRISTINE SULPHATE, MERCAPTOPURINE. Patient was hospitalized. Patient recovered.




Methotrexate Side Effects Report #5203401-7
Consumer or non-health professional from UNITED KINGDOM reported METHOTREXATE problem on Nov 22, 2006. Female patient, 52 years of age, was diagnosed with psoriasis and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: vaginal ulceration, vulval ulceration. METHOTREXATE dosage: 15MG WEEKLY - PO. Patient recovered.



Methotrexate Side Effects Report #5203590-4
METHOTREXATE problem was reported by a Health Professional from UNITED KINGDOM on Dec 20, 2006. Female patient, 73 years of age, was diagnosed with rheumatoid arthritis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: abdominal pain , aortic arteriosclerosis, aortic calcification, arteriosclerosis coronary artery, blood pressure diastolic decreased, bone marrow disorder, coronary artery occlusion, coronary artery thrombosis, dehydration. METHOTREXATE dosage: 7.5 MG, PO, QD;. During the same period patient was treated with PREDNISOLONE, FOLIC ACID, MORPHINE SULPHATE, ROFECOXIB, NITRAZEPAM. Patient was hospitalized. Patient died on 07/04/2004.



Methotrexate Side Effects Report #5205655-X
Pharmacist from UNITED STATES reported METHOTREXATE problem on Jan 05, 2007. Female patient, weighting 128.1 lb, was diagnosed with rheumatoid arthritis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, asthenia, decreased appetite, dyspnoea, pancytopenia, platelet count increased, white blood cell count decreased. METHOTREXATE dosage: 7.5 MG PO Q WEEK. During the same period patient was treated with NIFEDIPINE, CALCIUM, DIGOXIN, ALENDRONATE, ISOSORBIDE, FUROSEMIDE, OMEPRAZOLE, PREDNISONE. Patient was hospitalized. Patient recovered.



Methotrexate Side Effects Report #5205749-9
METHOTREXATE problem was reported by a Health Professional from BELGIUM on Jan 09, 2007. Male patient, 66 years of age, was diagnosed with psoriatic arthropathy and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: bone marrow failure, candidiasis, dermatitis exfoliative, hepatosplenomegaly, hepatotoxicity, mouth ulceration, nausea, pyrexia, stomatitis. METHOTREXATE dosage: unknown. During the same period patient was treated with FOLIC ACID. Patient was hospitalized. Patient recovered.



Methotrexate Side Effects Report #5208525-6
Consumer or non-health professional from reported METHOTREXATE problem on Jan 10, 2007. Female patient, child 7 years of age, was diagnosed with juvenile arthritis and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, cough, granuloma, histoplasmosis, lymphadenopathy, nodule, pharyngolaryngeal pain, pyrexia, splenomegaly. METHOTREXATE dosage: 12.5 MG/WEEK. During the same period patient was treated with PREDNISONE, NAPROXEN. Patient was hospitalized. Patient recovered.




Methotrexate Side Effects Report #5209342-3
METHOTREXATE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 29, 2006. Male patient was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, appetite disorder, cerebral palsy, developmental coordination disorder, developmental delay, gastrointestinal disorder, gastrooesophageal reflux disease, learning disorder. METHOTREXATE dosage: unknown. Patient recovered.



Methotrexate Side Effects Report #5213148-9
Consumer or non-health professional from UNITED STATES reported METHOTREXATE problem on Jan 18, 2007. Female patient, weighting 99.87 lb, was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: anxiety , brain oedema, central nervous system lesion, cognitive disorder, decreased appetite, facial paresis, gaze palsy, headache . METHOTREXATE dosage: 45 MG. During the same period patient was treated with CYCLOPHOSPHAMIDE, CYTARABINE, DEXAMETHASONE, DOXORUBICIN HYDROCHLORIDE, LEUCOVORIN CALCIUM, THIOGUANINE, VINCRISTINE SULPHATE. Patient was hospitalized. Patient recovered.



Methotrexate Side Effects Report #5213452-4
METHOTREXATE problem was reported by a Health Professional from UNITED STATES on Jan 08, 2007. Female patient, 27 years of age, was diagnosed with abortion induced and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: induced labour, pre-eclampsia, pregnancy. METHOTREXATE dosage: unknown. During the same period patient was treated with MISOPROSTOL. Patient recovered.



Methotrexate Side Effects Report #5215816-1
Consumer or non-health professional from FINLAND reported METHOTREXATE problem on Jan 19, 2007. Female patient, 14 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: bone marrow failure, gait disturbance, guillain-barre syndrome , neurogenic bladder, osteonecrosis , paraplegia, protein total decreased. METHOTREXATE dosage: unknown. During the same period patient was treated with CYTARABINE, PREDNISOLONE, PREDNISONE. Patient recovered.



Methotrexate Side Effects Report #5215961-0
METHOTREXATE problem was reported by a Consumer or non-health professional from FINLAND on Jan 19, 2007. Male patient, child 7 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: micturition disorder, paraplegia. METHOTREXATE dosage: unknown. Patient recovered.




Methotrexate Side Effects Report #5216114-2
Health Professional from SPAIN reported METHOTREXATE problem on Jan 22, 2007. Male patient, 37 years of age, was diagnosed with ankylosing spondylitis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: anaemia, gastrointestinal haemorrhage, kaposi's sarcoma . METHOTREXATE dosage: unknown. During the same period patient was treated with INFLIXIMAB, PREDNISONE, NONSTEROIDAL ANTI. Patient recovered.



Methotrexate Side Effects Report #5216233-0
METHOTREXATE problem was reported by a Consumer or non-health professional from on Jan 16, 2007. Female patient, 46 years of age, was diagnosed with rheumatoid arthritis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: anaphylactic reaction, blood pressure decreased, chest discomfort, face oedema, periorbital oedema, rash macular, urticaria. METHOTREXATE dosage: 25 MG WEEKLY X 10 MONTHS. During the same period patient was treated with ETANERCEPT, PREDNISOLONE, SULFASALAZOPYRIDINE, CYCLOSPORINE. Patient recovered.



Methotrexate Side Effects Report #5216875-2
Consumer or non-health professional from UNITED STATES reported METHOTREXATE problem on Jan 08, 2007. Female patient, 32 years of age, was diagnosed with ectopic pregnancy and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: abdominal pain lower, bone marrow failure, thrombocytopenia, uterine enlargement, uterine haemorrhage. METHOTREXATE dosage: unknown. Patient recovered.



Methotrexate Side Effects Report #5222677-3
METHOTREXATE problem was reported by a Physician from UNITED KINGDOM on Jan 08, 2007. Female patient, 74 years of age, was diagnosed with rheumatoid arthritis , urinary tract infection and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: bone marrow failure, clostridial infection, contraindication to medical treatment, diarrhoea, fall, haematuria, hip fracture. METHOTREXATE dosage: unknown. During the same period patient was treated with TRIMETHOPRIM, FOLATE, CIPROFLOXACIN. Patient died on 09/03/2005.



Methotrexate Side Effects Report #5223319-3
Consumer or non-health professional from UNITED KINGDOM reported METHOTREXATE problem on Jan 10, 2007. Male patient, 30 years of age, was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: birth mark, testicular disorder. METHOTREXATE dosage: unknown. Patient recovered.




Methotrexate Side Effects Report #5223885-8
METHOTREXATE problem was reported by a Consumer or non-health professional from UNITED KINGDOM on Jan 10, 2007. Male patient, 30 years of age, was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: birth mark, pregnancy, treatment noncompliance. METHOTREXATE dosage: unknown. Patient recovered.



Methotrexate Side Effects Report #5224083-4
Health Professional from UNITED STATES reported METHOTREXATE problem on Jan 29, 2007. Male patient, 15 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: intussusception. METHOTREXATE dosage: unknown. Patient recovered.



Methotrexate Side Effects Report #5224088-3
METHOTREXATE problem was reported by a Health Professional from UNITED STATES on Jan 29, 2007. Female patient, child 8 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: intussusception. METHOTREXATE dosage: unknown. Patient recovered.



Methotrexate Side Effects Report #5224111-6
Consumer or non-health professional from GERMANY reported METHOTREXATE problem on Jan 12, 2007. Male patient, child 7 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: areflexia, arthralgia, bone marrow disorder, central nervous system lesion, diplegia, disease recurrence, hypotonia, ill-defined disorder, meningism. METHOTREXATE dosage: unknown. Patient recovered.



Methotrexate Side Effects Report #5224683-1
METHOTREXATE problem was reported by a Pharmacist from UNITED STATES on Jan 29, 2007. Male patient, 65 years of age, weighting 235.4 lb, was diagnosed with scleritis and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: back pain , bacteria urine, bronchopneumonia, chills, diarrhoea, dyspnoea, hypotension, lung infiltration. METHOTREXATE dosage: 25MG EVERY WEEK SQ. Patient was hospitalized. Patient recovered.



Methotrexate Side Effects Report #5225359-7
Consumer or non-health professional from reported METHOTREXATE problem on Jan 29, 2007. Male patient, 37 years of age, was diagnosed with ankylosing spondylitis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: anaemia, gastrointestinal haemorrhage, kaposi's sarcoma , pancreatic neoplasm, skin nodule. METHOTREXATE dosage: 7.5 - 10 MG/WEEK. During the same period patient was treated with PREDNISONE, INFLIXIMAB, NONSTERIODAL ANTI. Patient recovered.



Methotrexate Side Effects Report #5225911-9
METHOTREXATE problem was reported by a Physician from SPAIN on Jan 17, 2007. Male patient, 37 years of age, was diagnosed with ankylosing spondylitis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: anaemia, antibody test positive, disease progression, gastrointestinal ulcer haemorrhage, kaposi's sarcoma , mouth plaque, nodule. METHOTREXATE dosage: 7.5 MG - 10 MG/QW. During the same period patient was treated with PREDNISONE, INFLIXIMAB, ANTIINFLAMMATORY. Patient was hospitalized. Patient recovered.



Methotrexate Side Effects Report #5226033-3
Consumer or non-health professional from GERMANY reported METHOTREXATE problem on Jan 17, 2007. Male patient, child 7 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: arthralgia, bone pain, faecal incontinence, gait disturbance, guillain-barre syndrome , meningism, micturition disorder, quadriplegia. METHOTREXATE dosage: (12 MG). Patient recovered.



Methotrexate Side Effects Report #5226902-4
METHOTREXATE problem was reported by a Physician from NETHERLANDS on Jan 18, 2007. Female patient, 46 years of age, was diagnosed with rheumatoid arthritis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: anaphylactic reaction. METHOTREXATE dosage: 25 MG WEEKLY SC. During the same period patient was treated with ETANERCEPT, PREDNISOLONE. Patient recovered.



Methotrexate Side Effects Report #5228751-X
Consumer or non-health professional from GERMANY reported METHOTREXATE problem on Jan 19, 2007. Female patient, 14 years of age, was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, arthralgia, aspartate aminotransferase increased, asthenia, atonic urinary bladder, blood immunoglobulin a decreased, blood immunoglobulin m decreased, bone marrow failure, gait disturbance. METHOTREXATE dosage: 12 MG PER_CYCLE IT. During the same period patient was treated with CYTARABINE, PREDNISOLONE, IBUPROFEN. Patient recovered.



Methotrexate Side Effects Report #5229617-1
METHOTREXATE problem was reported by a Health Professional from UNITED STATES on Jan 18, 2007. Male patient, 74 years of age, weighting 185.0 lb, was diagnosed with multiple sclerosis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: pyelonephritis, urinary tract infection. METHOTREXATE dosage: unknown. During the same period patient was treated with DITROPAN, HYTRIN, AMANTADINE, AVODART. Patient was hospitalized. Patient recovered.



Methotrexate Side Effects Report #5229794-2
Consumer or non-health professional from JAPAN reported METHOTREXATE problem on Jan 31, 2007. Male patient, 45 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: colitis, graft versus host disease, opportunistic infection. METHOTREXATE dosage: unknown. During the same period patient was treated with PREDNISOLONE, CYCLOSPORINE. Patient died.



Methotrexate Side Effects Report #5229974-6
METHOTREXATE problem was reported by a Consumer or non-health professional from JAPAN on Jan 31, 2007. Female patient, 43 years of age, was diagnosed with stem cell transplant and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: confusional state, convulsion, csf virus identified, graft versus host disease, human herpes virus 6 serology positive, meningoencephalitis herpetic, nuclear magnetic resonance imaging brain abnormal. METHOTREXATE dosage: unknown. During the same period patient was treated with CYCLOSPORINE. Patient died.



Methotrexate Side Effects Report #5231603-2
Consumer or non-health professional from UNITED STATES reported METHOTREXATE problem on Jan 24, 2007. Male patient, weighting 25.00 lb, was diagnosed with abortion  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: agitation, blood test abnormal, congenital anomaly, dehydration, diarrhoea, faeces discoloured, gait disturbance, gastrooesophageal reflux disease. METHOTREXATE dosage: unknown. Patient recovered.



Methotrexate Side Effects Report #5233866-6
METHOTREXATE problem was reported by a Health Professional from UNITED KINGDOM on Jan 18, 2007. Male patient, 66 years of age, was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: alveolitis, pleural effusion, pulmonary fibrosis , pulmonary oedema, respiratory tract infection, subcutaneous emphysema. METHOTREXATE dosage: 7.5 MG DAILY. During the same period patient was treated with HUMIRA, CALCIUM, FOLIC ACID, FUROSEMIDE, HYDROCHLOROQUINE, LANOPRAZOLE, MAGNESIUM HYDROXIDE, NAPROXEN. Patient was hospitalized. Patient recovered.



Methotrexate Side Effects Report #5236523-5
Consumer or non-health professional from ISRAEL reported METHOTREXATE problem on Jan 26, 2007. Male patient, 52 years of age, was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: hepatotoxicity, jaundice cholestatic, liver disorder. METHOTREXATE dosage: unknown. During the same period patient was treated with VINCRISTINE, DAUNORUBICIN, CYTARABINE, DEXAMETHASONE, CYCLOPHOSPHAMIDE, ASPARAGINASE, MERCAPTOPURINE, LAMIVUDINE. Patient recovered.



Methotrexate Side Effects Report #5236539-9
METHOTREXATE problem was reported by a Consumer or non-health professional from NETHERLANDS on Jan 30, 2007. Male patient, 60 years of age, was diagnosed with rheumatoid arthritis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: acute myeloid leukaemia, myelodysplastic syndrome, pancreatic carcinoma, photosensitivity reaction. METHOTREXATE dosage: 25 MG/ML (25 MG/ML, ONCE A WEEK). During the same period patient was treated with CALCIUM CARBONATE, MELOXICAM, FAMOTIDINE, FOLIC ACID, ACETYLSALICYLIC ACID SRT. Patient was hospitalized. Patient died.



Methotrexate Side Effects Report #5238295-7
Health Professional from TURKEY reported METHOTREXATE problem on Feb 06, 2007. Male patient was diagnosed with bone marrow transplant and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: acidosis, diarrhoea, febrile neutropenia, graft versus host disease, hepatic enzyme increased, hyperkeratosis, jaundice , rash erythematous, skin lesion. METHOTREXATE dosage: 10 MG/M2/D. During the same period patient was treated with BUSULFEX, CYCLOPHOSPHAMIDE, CYCLOSPORINE, IMMUNOGLOBULINS, FLUCONAZOLE, ACYCLOVIR, METRONIDAZOLE. Patient died.



Methotrexate Side Effects Report #5238652-9
METHOTREXATE problem was reported by a Pharmacist from UNITED STATES on Feb 14, 2007. Female patient, 84 years of age, weighting 138.0 lb, was diagnosed with rheumatoid arthritis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: anaemia, white blood cell count decreased. METHOTREXATE dosage: 10 MG EVERY MONDAY. Patient was hospitalized. Patient recovered.



Methotrexate Side Effects Report #5238708-0
Consumer or non-health professional from reported METHOTREXATE problem on Feb 12, 2007. Female patient, 45 years of age, was diagnosed with rheumatoid arthritis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: mucosal inflammation, pancytopenia, pyrexia. METHOTREXATE dosage: 12.5 MG/WEEK. During the same period patient was treated with HYDROXYCHLOROQUINE SULPHATE, NSAID. Patient recovered.



Methotrexate Side Effects Report #5238709-2
METHOTREXATE problem was reported by a Consumer or non-health professional from on Feb 12, 2007. Female patient, 46 years of age, was diagnosed with rheumatoid arthritis  and was treated with METHOTREXATE. After drug was administered, patient experienced the following problems/side effects: mucosal inflammation, pancytopenia, pyrexia. METHOTREXATE dosage: 7.5 MG/WEEK. During the same period patient was treated with NSAID. Patient recovered.

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