Pemetrexed Safety Questions, Pemetrexed Answers
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Pemetrexed Safety Reports
Total Pemetrexed reports: 132.Pemetrexed FDA safety alerts: No.
Reported deaths: 41 Reported hospitalizations: 89.
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Reported Pemetrexed Side Effects: haemoglobin decreased, thrombocytopenia, atrial fibrillation, nausea, interstitial lung disease, hepatic function abnormal, white blood cell count decreased, pyrexia, pneumonia, anaemia, dyspnoea.
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Showing 1-50 of 132 Next >
Pemetrexed Side Effects Report #5071752-5Physician from FRANCE reported PEMETREXED problem on July 20, 2006. Female patient, 50 years of age, was diagnosed with lung neoplasm malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: hepatocellular damage, lung neoplasm malignant, malignant neoplasm progression. PEMETREXED dosage: unknown. Patient recovered.
Pemetrexed Side Effects Report #5073096-4
PEMETREXED problem was reported by a Consumer or non-health professional from UNITED STATES on July 11, 2006. Male patient, 59 years of age, weighting 166.7 lb, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: radiation oesophagitis. PEMETREXED dosage: 995 MG/M2, OTHER, INTRAVENOUS. During the same period patient was treated with CARBOPLATIN, FOLIC ACID, CYANOCOBALAMIN, ADVAIR DISKUS, XANAX, COMPAZINE, EMEND. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5079715-0
Physician from UNITED STATES reported PEMETREXED problem on July 18, 2006. Male patient, 80 years of age, weighting 176.4 lb, was diagnosed with pleural mesothelioma and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: bronchopneumonia, diffuse alveolar damage, haemodynamic instability, hypotension, lobar pneumonia, platelet count decreased, radiation pneumonitis, respiratory failure, resuscitation. PEMETREXED dosage: 500 MG/M2, OTHER, INTRAVENOUS. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient died on 05/26/2006.
Pemetrexed Side Effects Report #5089069-1
PEMETREXED problem was reported by a Consumer or non-health professional from SWEDEN on Aug 03, 2006. Male patient, 64 years of age, was diagnosed with lung neoplasm malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: dermatitis bullous, livedo reticularis, respiratory disorder, weight decreased. PEMETREXED dosage: 950 MG, OTHER, INTRAVENOUS. During the same period patient was treated with FOLACIN, BETAPRED, SPIRONOLACTONE, OXYCONTIN. Patient was hospitalized. Patient died on 05/24/2006.
Pemetrexed Side Effects Report #5102489-1
Health Professional from UNITED STATES reported PEMETREXED problem on Aug 18, 2006. Male patient, 67 years of age, weighting 156.5 lb, was diagnosed with prostate cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: activated partial thromboplastin time prolonged, asthenia, blood alkaline phosphatase increased, blood calcium decreased, cerebrovascular accident, disseminated intravascular coagulation, dysarthria, extensor plantar response, facial palsy. PEMETREXED dosage: 890 MG, OTHER, INTRAVENOUS. During the same period patient was treated with CYANOCOBALAMIN, FOLIC ACID, PREVACID, WARFARIN. Patient was hospitalized. Patient died on 10/25/2005.
Pemetrexed Side Effects Report #5106537-4
PEMETREXED problem was reported by a Consumer or non-health professional from UNITED KINGDOM on Aug 24, 2006. Female patient, 49 years of age, was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: blood magnesium decreased. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient recovered.
Pemetrexed Side Effects Report #5117694-8
Physician from FRANCE reported PEMETREXED problem on Sept 15, 2006. Male patient, 60 years of age, was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: acute respiratory failure, catheter site phlebitis, pericarditis, pneumonitis, recall phenomenon. PEMETREXED dosage: 500 MG/M2, OTHER, INRAVENOUS. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5120638-6
PEMETREXED problem was reported by a Consumer or non-health professional from BELGIUM on Sept 11, 2006. Male patient, 64 years of age, was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: febrile neutropenia, pneumonia. PEMETREXED dosage: 938.8MG, OTHER, INTRAVENOUS. During the same period patient was treated with RADIATION. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5130278-0
Pharmacist from UNITED STATES reported PEMETREXED problem on Oct 18, 2006. Male patient, 76 years of age, weighting 200.0 lb, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: asthenia, haemoglobin decreased, neutropenia, tachycardia. PEMETREXED dosage: 1000 MG IV. During the same period patient was treated with VALSARTAN, TEMAZEPAM, FOLIC ACID, PROMETHAZINE, METOPROLOL, GLYBURIDE, METFORMIN, SIMVASTATIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5139902-X
PEMETREXED problem was reported by a Physician from INDIA on Sept 19, 2006. Male patient, 51 years of age, weighting 92.59 lb, was diagnosed with non-small cell lung cancer, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: dysphagia, dysphonia, dysuria, fatigue, micturition disorder, paraplegia, spinal disorder. PEMETREXED dosage: 725 MG, ONCE IN 3 WEEKS. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5140046-1
Physician from UNITED STATES reported PEMETREXED problem on Oct 09, 2006. Male patient, 57 years of age, weighting 162.9 lb, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: abscess intestinal, diverticular perforation, peritonitis. PEMETREXED dosage: 940 MG, OTHER, INTRAVENOUS. During the same period patient was treated with CARBOPLATIN, FOLIC ACID, CYANOCOBALAMIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5141771-9
PEMETREXED problem was reported by a Consumer or non-health professional from UNITED KINGDOM on Oct 12, 2006. Male patient, 49 years of age, weighting 315.3 lb, was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: blood magnesium decreased. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5142788-0
Physician from UNITED STATES reported PEMETREXED problem on Oct 09, 2006. Male patient, 72 years of age, weighting 190.5 lb, was diagnosed with mesothelioma and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, platelet count increased, pyrexia, rash maculo-papular, sinusitis, upper respiratory tract infection, white blood cell count decreased. PEMETREXED dosage: 1000 MG, OTHER, INTRAVENOUS. During the same period patient was treated with GEMCITABINE, VITAMIN B12, FOLIC ACID, VITAMIN C, VITAMIN E, VITAMIN B CAP, FLOMAX, RITALIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5145089-X
PEMETREXED problem was reported by a Physician from ARGENTINA on Feb 08, 2005. Male patient, 67 years of age, weighting 154.8 lb, was diagnosed with lung neoplasm malignant, prophylaxis, prophylaxis of nausea and vomiting and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, blood urea increased, depressed level of consciousness, respiratory disorder. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, FOLIC ACID, VITAMIN B, ONDANSETRON, TRAMADOL, ENALAPRIL MALEATE, RANITIDINE, DEXAMETHASONE. Patient died on 02/06/2005.
Pemetrexed Side Effects Report #5150410-2
Physician from FRANCE reported PEMETREXED problem on Oct 30, 2006. Female patient, 75 years of age, was diagnosed with lung neoplasm malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anaemia, breast induration, breast pain, disease progression, fatigue, nausea, recall phenomenon. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with GEMZAR, CARBOPLATIN, FOLIC ACID, VITAMIN B CAP, PREDNISOLONE. Patient recovered.
Pemetrexed Side Effects Report #5150883-5
PEMETREXED problem was reported by a Consumer or non-health professional from GREECE on Apr 10, 2006. Male patient, 76 years of age, weighting 187.4 lb, was diagnosed with non-small cell lung cancer, soft tissue infection, bone pain and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: erythema multiforme, jaundice, malignant neoplasm progression, neutropenia, thrombocytopenia. PEMETREXED dosage: unknown. During the same period patient was treated with FUCIDIN, ZOMETA. Patient was hospitalized. Patient died.
Pemetrexed Side Effects Report #5151818-1
Health Professional from UNITED STATES reported PEMETREXED problem on Oct 18, 2006. Male patient, 57 years of age, weighting 162.9 lb, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: abscess, disease progression, diverticular perforation, diverticulitis, mucosal inflammation, peritonitis, pyrexia. PEMETREXED dosage: 940 MG, OTHER, INTRAVENOUS. During the same period patient was treated with CARBOPLATIN, BEVACIZUMAB, FOLIC ACID, CYANOCOBALAMIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5152475-0
PEMETREXED problem was reported by a Physician from HUNGARY on Nov 06, 2006. Male patient, 64 years of age, was diagnosed with mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: completed suicide. PEMETREXED dosage: 1000 MG, UNK. During the same period patient was treated with FUROSEMIDE, VITAMIN B, VEROSPIRON, CONTRAMAL, FOLIC ACID. Patient died on 11/02/2006.
Pemetrexed Side Effects Report #5154979-3
Physician from GREECE reported PEMETREXED problem on Nov 10, 2006. Male patient, 64 years of age, weighting 220.5 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: liver disorder. PEMETREXED dosage: 1000 MG,. During the same period patient was treated with CARBOPLATIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5155045-3
PEMETREXED problem was reported by a Physician from UNITED STATES on Nov 13, 2006. Male patient, 47 years of age, was diagnosed with mesothelioma malignant, vitamin supplementation and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: mouth ulceration, nausea, pneumonia, vomiting. PEMETREXED dosage: 500 MG/M2, UNK. During the same period patient was treated with CARBOPLATIN, CISPLATIN, FOLIC ACID, VITAMIN B. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5157884-1
Physician from ARGENTINA reported PEMETREXED problem on Feb 08, 2005. Male patient, 67 years of age, weighting 154.8 lb, was diagnosed with lung neoplasm malignant, prophylaxis, prophylaxis of nausea and vomiting and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, blood urea increased, depressed level of consciousness, dyspnoea, renal failure, respiratory disorder. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, FOLIC ACID, VITAMIN B, ONDANSETRON, TRAMADOL, ENALAPRIL MALEATE, RANITIDINE, DEXAMETHASONE. Patient died on 02/06/2005.
Pemetrexed Side Effects Report #5158674-6
PEMETREXED problem was reported by a Physician from GREECE on Nov 10, 2006. Male patient, 64 years of age, weighting 220.5 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: liver disorder, viral infection. PEMETREXED dosage: 1000 MG,. During the same period patient was treated with CARBOPLATIN, FOLIC ACID, VITAMIN B. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5164693-6
Physician from GREECE reported PEMETREXED problem on Nov 10, 2006. Male patient, 64 years of age, weighting 220.5 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: hepatic enzyme increased, liver disorder. PEMETREXED dosage: 1000 MG,. During the same period patient was treated with CARBOPLATIN, FOLIC ACID, VITAMIN B. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5169310-7
PEMETREXED problem was reported by a Physician from ITALY on July 19, 2006. Male patient, 63 years of age, weighting 209.4 lb, was diagnosed with pleural mesothelioma, prophylaxis, anaemia and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: activated partial thromboplastin time prolonged, alanine aminotransferase increased, aspartate aminotransferase increased, blood amylase increased, blood bilirubin increased, blood calcium decreased, blood cholinesterase decreased, blood fibrinogen increased, blood lactate dehydrogenase increased. PEMETREXED dosage: 950 MG, OTHER. During the same period patient was treated with CISPLATIN, TORADOL, MEPRAL, CLEXANE, FERROGRAD. Patient was hospitalized. Patient died on 07/24/2006.
Pemetrexed Side Effects Report #5174404-6
Physician from UNITED STATES reported PEMETREXED problem on Nov 13, 2006. Male patient, 47 years of age, weighting 140.0 lb, was diagnosed with mesothelioma malignant, vitamin supplementation and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: mucosal inflammation, nausea, pneumonia, vomiting. PEMETREXED dosage: 500 MG/M2, UNK. During the same period patient was treated with CARBOPLATIN, CISPLATIN, FOLIC ACID, VITAMIN B. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5179587-X
PEMETREXED problem was reported by a Physician from FINLAND on Sept 04, 2006. Male patient, 66 years of age, was diagnosed with mesothelioma, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: brain oedema, dysarthria, facial palsy, reversible posterior leukoencephalopathy syndrome. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN, NEXIUM, FOLVITE. Patient was hospitalized and became disabled. Patient recovered.
Pemetrexed Side Effects Report #5186485-4
Physician from UNITED KINGDOM reported PEMETREXED problem on Nov 29, 2005. Male patient, 68 years of age, weighting 212.3 lb, was diagnosed with non-small cell lung cancer, prophylaxis, myocardial infarction, angina pectoris, atrial fibrillation and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: flatulence, international normalised ratio increased, intestinal dilatation, intestinal perforation, neutrophil percentage decreased, peritonitis, platelet count decreased, rectal haemorrhage. PEMETREXED dosage: 1890 MG, OTHER. During the same period patient was treated with FOLIC ACID, VITAMIN B, DILTIAZEM, NICORANDIL, ALLOPURINOL, WARFARIN, FLUVASTATIN. Patient was hospitalized. Patient died on 11/28/2005.
Pemetrexed Side Effects Report #5377503-9
PEMETREXED problem was reported by a Physician from JAPAN on June 21, 2007. Male patient, 75 years of age, weighting 145.5 lb, was diagnosed with prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, hepatic function abnormal, neutrophil count decreased, platelet count decreased, white blood cell count decreased. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, CYANOCOBALAMIN, SEROTONE, DECADRON, ROHYPNOL, NAUZELIN, SEPAMIT. Patient recovered.
Pemetrexed Side Effects Report #5383223-7
Physician from FRANCE reported PEMETREXED problem on June 26, 2007. Male patient, 85 years of age, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: toxic epidermal necrolysis. PEMETREXED dosage: unknown. Patient recovered.
Pemetrexed Side Effects Report #5389684-1
PEMETREXED problem was reported by a Physician from POLAND on July 09, 2007. Male patient, 58 years of age, weighting 174.2 lb, was diagnosed with small cell lung cancer extensive stage and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: cerebral haemorrhage, thrombocytopenia. PEMETREXED dosage: 500 MG/M2, DAY 1 OF 21 DAY CYCLE. During the same period patient was treated with CARBOPLATIN, FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient died on 07/09/2007.
Pemetrexed Side Effects Report #5389686-5
Physician from reported PEMETREXED problem on July 04, 2007. Female patient, 59 years of age, weighting 123.0 lb, was diagnosed with lung neoplasm malignant, dyspepsia, metastases to central nervous system, candidiasis, pain, sleep disorder and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: dyspnoea, febrile neutropenia. PEMETREXED dosage: 762.5 MG, EVERY 21 DAYS. During the same period patient was treated with VITAMINS WITH MINERALS, OMEPRAZOLE, BETAMETHASONE, FLUKONAZOL, CODEINE W, FENTANYL, PREGABALIN, PROPIOMAZINE. Patient was hospitalized. Patient died.
Pemetrexed Side Effects Report #5389687-7
PEMETREXED problem was reported by a Physician from SPAIN on July 04, 2007. Male patient, 52 years of age, weighting 110.2 lb, was diagnosed with neoplasm malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: laryngeal dyspnoea. PEMETREXED dosage: 500 MG/M2, UNK. During the same period patient was treated with CISPLATIN, FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5389688-9
Physician from RUSSIAN FEDERATION reported PEMETREXED problem on June 09, 2007. Male patient, 55 years of age, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: pulmonary haemorrhage, tumour necrosis. PEMETREXED dosage: unknown. During the same period patient was treated with FOLIC ACID, VITAMIN B, VERAPAMIL, DEXAMETHASONE, CIPROFLOXACIN, EUPHYLLIN. Patient was hospitalized. Patient died on 06/22/2006.
Pemetrexed Side Effects Report #5389692-0
PEMETREXED problem was reported by a Physician from INDIA on July 12, 2007. Male patient, 51 years of age, weighting 92.59 lb, was diagnosed with non-small cell lung cancer, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: dysphagia, fatigue, micturition disorder, paraplegia. PEMETREXED dosage: 725 MG, ONCE IN 3 WEEKS. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5389696-8
Physician from JAPAN reported PEMETREXED problem on July 10, 2007. Male patient, 61 years of age, weighting 120.9 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: interstitial lung disease. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient recovered.
Pemetrexed Side Effects Report #5391531-9
PEMETREXED problem was reported by a Physician from SPAIN on July 13, 2007. Male patient, 64 years of age, was diagnosed with mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: diarrhoea, neutropenia, pneumonia, renal failure. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient died on 03/01/2006.
Pemetrexed Side Effects Report #5394624-5
Physician from JAPAN reported PEMETREXED problem on July 09, 2007. Female patient, 67 years of age, weighting 121.3 lb, was diagnosed with pleural mesothelioma malignant, cryptogenic organising pneumonia and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: hepatic function abnormal, oedema peripheral, pneumonia staphylococcal, pyrexia, respiratory failure, sepsis, urine output decreased. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with PREDONINE, MUCODYNE, BISOLVON, LANSOPRAZOLE, LENDORM, ASPARA, ROCALTROL. Patient died on 03/11/2007.
Pemetrexed Side Effects Report #5394629-4
PEMETREXED problem was reported by a Physician from JAPAN on July 17, 2007. Male patient, 61 years of age, weighting 120.9 lb, was diagnosed with pleural mesothelioma malignant, tumour associated fever, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: interstitial lung disease. PEMETREXED dosage: 740 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, CYANOCOBALAMIN, PREDONINE, ZANTAC, WYPAX. Patient recovered.
Pemetrexed Side Effects Report #5394630-0
Physician from JAPAN reported PEMETREXED problem on July 13, 2007. Female patient, 77 years of age, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: aneurysm, atrial fibrillation, cardiac failure, hypoproteinaemia, oedema, renal impairment. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5394631-2
PEMETREXED problem was reported by a Physician from JAPAN on July 17, 2007. Male patient, 75 years of age, weighting 145.5 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: bone marrow failure, hepatic function abnormal, neutrophil count decreased, renal impairment. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, SEROTONE, DECADRON, ROHYPNOL, NAUZELIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5398022-X
Physician from JAPAN reported PEMETREXED problem on July 13, 2007. Female patient, 71 years of age, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: cholelithiasis, gastritis, pseudomonal sepsis. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, FAMOTIDINE, OMEPRAZOLE. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5400686-9
PEMETREXED problem was reported by a Physician from FRANCE on July 18, 2007. Male patient, 85 years of age, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: toxic epidermal necrolysis. PEMETREXED dosage: unknown. Patient recovered.
Pemetrexed Side Effects Report #5403041-0
Physician from JAPAN reported PEMETREXED problem on July 18, 2007. Male patient, 59 years of age, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient recovered.
Pemetrexed Side Effects Report #5406469-8
PEMETREXED problem was reported by a Physician from RUSSIAN FEDERATION on July 26, 2007. Male patient, 55 years of age, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: malignant neoplasm progression. PEMETREXED dosage: unknown. During the same period patient was treated with FOLIC ACID, VITAMIN B, VERAPAMIL, DEXAMETHASONE, CIPROFLOXACIN, EUPHYLLIN. Patient was hospitalized. Patient died on 06/22/2006.
Pemetrexed Side Effects Report #5406473-X
Physician from JAPAN reported PEMETREXED problem on July 26, 2007. Male patient, 62 years of age, weighting 101.9 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: blood sodium decreased. PEMETREXED dosage: 700 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, NORVASC, DIART, CANDESARTAN CILEXETIL. Patient recovered.
Pemetrexed Side Effects Report #5406480-7
PEMETREXED problem was reported by a Physician from JAPAN on July 26, 2007. Male patient, 37 years of age, weighting 169.5 lb, was diagnosed with pleural mesothelioma malignant recurrent, rhinitis allergic, epilepsy, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: deafness neurosensory. PEMETREXED dosage: 960 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, TEGRETOL, KYTRIL. Patient recovered.
Pemetrexed Side Effects Report #5411378-4
Physician from JAPAN reported PEMETREXED problem on Aug 01, 2007. Female patient, 67 years of age, weighting 121.3 lb, was diagnosed with pleural mesothelioma malignant, cryptogenic organising pneumonia, iron deficiency anaemia, gastritis, insomnia, osteoporosis prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: lymphocyte count decreased, pneumonia, pneumonia staphylococcal, urine output decreased. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with PREDONINE, MUCODYNE, BISOLVON, LANSOPRAZOLE, LENDORMIN, ASPARA, ROCALTROL. Patient died on 03/11/2007.
Pemetrexed Side Effects Report #5411379-6
PEMETREXED problem was reported by a Physician from JAPAN on Aug 02, 2007. Male patient, 54 years of age, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: pneumonia, pulmonary necrosis. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5413763-3
Physician from JAPAN reported PEMETREXED problem on Aug 06, 2007. Male patient, 61 years of age, weighting 120.9 lb, was diagnosed with pleural mesothelioma malignant, tumour associated fever, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: gastrointestinal haemorrhage, interstitial lung disease. PEMETREXED dosage: 740 MG, OTHER. During the same period patient was treated with PANVITAN, CYANOCOBALAMIN, PREDONINE, ZANTAC, LORAZEPAM. Patient died on 08/04/2007.
Pemetrexed Side Effects Report #5413764-5
PEMETREXED problem was reported by a Physician from JAPAN on July 30, 2007. Female patient, 71 years of age, weighting 122.8 lb, was diagnosed with pleural mesothelioma malignant, hypertension, neurogenic bladder, major depression and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with PANVITAN, METHYCOBAL, DIOVAN, NORVASC, UBRETID, PAXIL. Patient recovered.
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Drug Information: Pemetrexed Injection
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a607043.html
(pem'' e trex' ed)Why is this medication prescribed?
Pemetrexed is used with another chemotherapy (anti-cancer) medication to treat malignant pleural mesothelioma (a type of cancer that affects the inside lining of the chest cavity). Pemetrexed is also used to treat non-small cell lung cancer. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by blocking the action of a certain substance in the body that may help cancer cells multiply.
How should this medicine be used?
Pemetrexed comes as a solution (liquid) to be injected into a vein. Pemetrexed is administered by a doctor or nurse in a medical office or infusion center. It is usually given once every 21 days.
Your doctor will probably tell you to take other medications, such as folic acid (a vitamin), vitamin B12, and a corticosteroid such as dexamethasone (Decadron) to decrease some of the side effects of this medication. Your doctor will give you directions for taking these medications. Follow your doctor's directions carefully. Ask your doctor or pharmacist to explain any part you do not understand. If you miss a dose of one of these medications, call your doctor.
Your doctor will ask you to have regular blood tests before and during treatment with pemetrexed. Your doctor may change your dose of pemetrexed or delay treatment based on the results of the blood tests.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking pemetrexed,
- tell your doctor and pharmacist if you are allergic to pemetrexed, mannitol,or any other medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), or probenecid. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have a pleural effusion (excess fluid between the linings around the lung), ascites (excess fluid in the abdomen); or have or have ever had kidney or liver disease.
- tell your doctor if you are pregnant or plan to become pregnant. You should use birth control to prevent pregnancy during your treatment with pemetrexed. If you become pregnant while using this medication, call your doctor. Pemetrexed may harm the fetus.
- tell your doctor if you are breast-feeding. You should not breast-feed during your treatment with pemetrexed.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
If you miss an appointment to receive a dose of pemetrexed, call your doctor as soon as possible.
What side effects can this medication cause?
Pemetrexed may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea
- vomiting
- constipation
- loss of appetite
- weight loss
- tiredness
- weakness
- pale skin
- headache
- dizziness
- confusion
- fast heartbeat
- difficulty falling asleep or staying asleep
- changes in mood
- depression
- joint or muscle pain
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
- diarrhea
- sores and/or redness in the mouth or throat or on the lips
- unusual bleeding or bruising
- sore throat, fever, chills, cough or other signs of infection
- chest pain
- difficulty breathing or swallowing
- slow or difficult speech
- dizziness or faintness
- weakness or numbness of an arm or leg
- pain, burning, numbness, or tingling in the hands or feet
- hives
- rash
- itching
- decreased urination
Pemetrexed may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- rash
- sores and/or redness in the mouth or throat or on the lips
- unusual bleeding or bruising
- sore throat, fever, chills, cough or other signs of infection
- extreme tiredness
- weakness
- pale skin
- headache
- dizziness
- confusion
- fast heartbeat
- difficulty falling asleep or staying asleep
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to pemetrexed.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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