Common Plavix Side Effects


The most commonly reported Plavix side effects (click to view or check a box to report):

Myocardial Infarction (300)
Dyspnoea (270)
Anaemia (263)
Contusion (260)
Asthenia (251)
Death (238)
Cerebrovascular Accident (215)
Gastrointestinal Haemorrhage (207)
Dizziness (204)
Chest Pain (200)
Haemorrhage (176)
Fall (166)
Fatigue (162)
Headache (152)
Haemoglobin Decreased (145)
Diarrhoea (137)
Nausea (132)
Epistaxis (132)
Pruritus (129)
Coronary Artery Occlusion (123)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Plavix Side Effects Reported to FDA



Plavix Side Effect Report#9995703
Asthenia, Decreased Appetite, Abdominal Pain Upper, Gastric Haemorrhage, Shock Haemorrhagic
This is a report of a 67-year-old male patient (weight: NA) from IT, suffering from the following health symptoms/conditions: thrombosis prophylaxis, who was treated with Plavix (dosage: NA, start time:
Jan 28, 2014), combined with:
  • Oki (Strength: 80 Mg)
  • Olmesartan Medoxomil
  • Pravastatin
  • Iperten
and developed a serious reaction and side effect(s): Asthenia, Decreased Appetite, Abdominal Pain Upper, Gastric Haemorrhage, Shock Haemorrhagic after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Plavix treatment in male patients, resulting in Asthenia side effect. The patient was hospitalized.
Plavix Side Effect Report#9995638
International Normalised Ratio Increased, Haemarthrosis, Anaemia, Haematochezia
This report suggests a potential Plavix International Normalised Ratio Increased side effect(s) that can have serious consequences. A 87-year-old female patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: thrombosis prophylaxis and used Plavix (dosage: NA) starting NS. After starting Plavix the patient began experiencing various side effects, including: International Normalised Ratio Increased, Haemarthrosis, Anaemia, HaematocheziaAdditional drugs used concurrently:
  • Previscan
The patient was hospitalized. Although Plavix demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as International Normalised Ratio Increased, may still occur.
Plavix Side Effect Report#9995626
Transient Ischaemic Attack, Dysarthria, Motor Dysfunction, Aphasia
This Transient Ischaemic Attack problem was reported by a health professional from FR. A 84-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On 2009 this consumer started treatment with Plavix (dosage: NA). The following drugs were being taken at the same time:
  • Kardegic (Dose Increased To 160 Mg)
  • Triatec
  • Tahor
  • Imovane
  • Sectral
When using Plavix, the patient experienced the following unwanted symptoms/side effects: Transient Ischaemic Attack, Dysarthria, Motor Dysfunction, AphasiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Transient Ischaemic Attack, may become evident only after a product is in use by the general population.
Plavix Side Effect Report#9989183
Aortic Valve Disease, Arthropathy, Pulmonary Congestion, Blood Disorder, International Normalised Ratio Decreased, Eye Disorder
This Aortic Valve Disease side effect was reported by a consumer or non-health professional from US. A male patient (weight:NA) experienced the following symptoms/conditions: transient ischaemic attack.The patient was prescribed Plavix (drug dosage: NA), which was initiated on 1996. Concurrently used drugs:
  • Aspirin
  • Warfarin (2 Mg 5 Days A Week)
  • Warfarin (1 Mg 2 Days A Week)
.After starting to take Plavix the consumer reported adverse symptoms, such as: Aortic Valve Disease, Arthropathy, Pulmonary Congestion, Blood Disorder, International Normalised Ratio Decreased, Eye DisorderThese side effects may potentially be related to Plavix. The patient was hospitalized.
Plavix Side Effect Report#9989155
Cardiac Failure Congestive, Pulmonary Oedema, Cough
This is a report of a 86-year-old male patient (weight: NA) from TW, suffering from the following health symptoms/conditions: NA, who was treated with Plavix (dosage: NA, start time:
Sep 28, 2013), combined with:
  • Furosemide
and developed a serious reaction and side effect(s): Cardiac Failure Congestive, Pulmonary Oedema, Cough after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Plavix treatment in male patients, resulting in Cardiac Failure Congestive side effect. The patient was hospitalized.
Plavix Side Effect Report#9973600
Metabolic Acidosis, Syncope, Hyperlactacidaemia, Anaemia, Gastric Haemorrhage, Subdural Haematoma
This report suggests a potential Plavix Metabolic Acidosis side effect(s) that can have serious consequences. A 74-year-old female patient (weight: NA) from IT was diagnosed with the following symptoms/conditions: NA and used Plavix (dosage: NA) starting
Jan 01, 2013. After starting Plavix the patient began experiencing various side effects, including: Metabolic Acidosis, Syncope, Hyperlactacidaemia, Anaemia, Gastric Haemorrhage, Subdural HaematomaAdditional drugs used concurrently:
  • Coumadin (Dose:1 Unit(s))
  • Cardicor
  • Lasix (Strength: 500 Mg)
  • Lasix (Strenght: 25 Mg)
  • Valsartan (Strength: 40 Mg Film Coated Tablet)
  • Torvast (Strength: 10 Mg)
The patient was hospitalized. Although Plavix demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Metabolic Acidosis, may still occur.
Plavix Side Effect Report#9973599
Metabolic Acidosis, Syncope, Hyperlactacidaemia, Anaemia, Gastric Haemorrhage, Subdural Haematoma
This Metabolic Acidosis problem was reported by a physician from IT. A 74-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jan 01, 2013 this consumer started treatment with Plavix (dosage: NA). The following drugs were being taken at the same time:
  • Coumadin (Dose:1 Unit(s))
  • Cardicor
  • Lasix (Strength: 500 Mg)
  • Lasix (Strenght: 25 Mg)
  • Valsartan (Strength: 40 Mg Film Coated Tablet)
  • Torvast (Strength: 10 Mg)
When using Plavix, the patient experienced the following unwanted symptoms/side effects: Metabolic Acidosis, Syncope, Hyperlactacidaemia, Anaemia, Gastric Haemorrhage, Subdural HaematomaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Metabolic Acidosis, may become evident only after a product is in use by the general population.
Plavix Side Effect Report#9963981
Transient Ischaemic Attack, Blood Disorder, Hypertension, Blood Cholesterol Increased, Cerebrovascular Accident, Gastrooesophageal Reflux Disease
This Transient Ischaemic Attack side effect was reported by a consumer or non-health professional from US. A female patient (weight:NA) experienced the following symptoms/conditions: cerebrovascular accident.The patient was prescribed Plavix (drug dosage: Taken From : 3 Years Ago), which was initiated on NS. Concurrently used drugs:
  • Lisinopril
  • Aspirin
  • Simvastatin
  • Ranitidine
.After starting to take Plavix the consumer reported adverse symptoms, such as: Transient Ischaemic Attack, Blood Disorder, Hypertension, Blood Cholesterol Increased, Cerebrovascular Accident, Gastrooesophageal Reflux DiseaseThese side effects may potentially be related to Plavix.
Plavix Side Effect Report#9942349
Hypertensive Heart Disease, Cardiovascular Disorder
This is a report of a 61-year-old male patient (weight: NA) from RU, suffering from the following health symptoms/conditions: thrombosis prophylaxis, who was treated with Plavix (dosage: NA, start time:
Jul 23, 2013), combined with: NA. and developed a serious reaction and side effect(s): Hypertensive Heart Disease, Cardiovascular Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Plavix treatment in male patients, resulting in Hypertensive Heart Disease side effect.
Plavix Side Effect Report#9942333
Chest Pain, Dyspnoea, Arterial Restenosis
This report suggests a potential Plavix Chest Pain side effect(s) that can have serious consequences. A 59-year-old male patient (weight: NA) from RU was diagnosed with the following symptoms/conditions: thrombosis prophylaxis,hypertension and used Plavix (dosage: NA) starting
Dec 17, 2013. After starting Plavix the patient began experiencing various side effects, including: Chest Pain, Dyspnoea, Arterial RestenosisAdditional drugs used concurrently:
  • Ramipril
  • Thrombo Ass
  • Betaloc (Strength: 100 Mg)
  • Liprimar (Strength: 40 Mg)
The patient was hospitalized. Although Plavix demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Chest Pain, may still occur.
Plavix Side Effect Report#9934961
Chest Discomfort, Muscle Spasms, Rectal Haemorrhage
This Chest Discomfort problem was reported by a consumer or non-health professional from US. A 68-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: myocardial infarction,coronary artery disease. On
Feb 11, 2013 this consumer started treatment with Plavix (dosage: NA). The following drugs were being taken at the same time: NA. When using Plavix, the patient experienced the following unwanted symptoms/side effects: Chest Discomfort, Muscle Spasms, Rectal HaemorrhageAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Chest Discomfort, may become evident only after a product is in use by the general population.
Plavix Side Effect Report#9931739
Toxoplasmosis, Cardiogenic Shock, Cardiac Disorder, Renal Failure Acute
This Toxoplasmosis side effect was reported by a health professional from US. A male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Plavix (drug dosage: NA), which was initiated on
May 17, 2012. Concurrently used drugs:
  • Aspirin
  • Belatacept
  • Nexium
  • Novolog (Sliding Scale)
  • Magnesium Oxide
  • Lopressor
  • Mycophenolate Mofetil
  • Procardia (Dose: 60 Mg And 30 Mg)
.After starting to take Plavix the consumer reported adverse symptoms, such as: Toxoplasmosis, Cardiogenic Shock, Cardiac Disorder, Renal Failure AcuteThese side effects may potentially be related to Plavix.
Plavix Side Effect Report#9931668
Chest Discomfort, Anaemia, Dizziness
This is a report of a 67-year-old female patient (weight: NA) from TW, suffering from the following health symptoms/conditions: NA, who was treated with Plavix (dosage: NA, start time:
Dec 26, 2013), combined with: NA. and developed a serious reaction and side effect(s): Chest Discomfort, Anaemia, Dizziness after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Plavix treatment in female patients, resulting in Chest Discomfort side effect. The patient was hospitalized.
Plavix Side Effect Report#9928341
Shock, Vessel Puncture Site Haematoma, Anaemia, Scrotal Haematoma
This report suggests a potential Plavix Shock side effect(s) that can have serious consequences. A 74-year-old male patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: NA and used Plavix (dosage: Strength: 75 Mg) starting
Jan 27, 2014. After starting Plavix the patient began experiencing various side effects, including: Shock, Vessel Puncture Site Haematoma, Anaemia, Scrotal HaematomaAdditional drugs used concurrently: NA.The patient was hospitalized. Although Plavix demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Shock, may still occur.
Plavix Side Effect Report#9928274
Haematemesis, Vertigo, Vomiting
This Haematemesis problem was reported by a physician from IT. A 66-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: myocardial ischaemia. On
Jan 01, 2013 this consumer started treatment with Plavix (dosage: NA). The following drugs were being taken at the same time:
  • Cardioaspirin
  • Tareg
When using Plavix, the patient experienced the following unwanted symptoms/side effects: Haematemesis, Vertigo, VomitingThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Haematemesis, may become evident only after a product is in use by the general population.
Plavix Side Effect Report#9919299
Lung Neoplasm Malignant
This Lung Neoplasm Malignant side effect was reported by a consumer or non-health professional from US. A 79-year-old female patient (weight:NA) experienced the following symptoms/conditions: coronary artery disease.The patient was prescribed Plavix (drug dosage: NA), which was initiated on
Oct 05, 2012. Concurrently used drugs:
  • Hydrochlorothiazide (12.5: Dose)
  • Symbicort (Dose: 80/4.5 Mg)
  • Folic Acid
  • Simvastatin
.After starting to take Plavix the consumer reported adverse symptoms, such as: Lung Neoplasm MalignantThese side effects may potentially be related to Plavix.
Plavix Side Effect Report#9916393
This is a report of a 68-year-old male patient (weight: NA) from RU, suffering from the following health symptoms/conditions: NA, who was treated with Plavix (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Plavix treatment in male patients, resulting in Death side effect.
Plavix Side Effect Report#9913769
Pleural Effusion, Dyspnoea
This report suggests a potential Plavix Pleural Effusion side effect(s) that can have serious consequences. A 81-year-old male patient (weight: NA) from TW was diagnosed with the following symptoms/conditions: myocardial ischaemia and used Plavix (dosage: NA) starting
Dec 30, 2013. After starting Plavix the patient began experiencing various side effects, including: Pleural Effusion, DyspnoeaAdditional drugs used concurrently:
  • Furosemide
The patient was hospitalized. Although Plavix demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pleural Effusion, may still occur.
Plavix Side Effect Report#9913580
Arrhythmia
This Arrhythmia problem was reported by a consumer or non-health professional from TR. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: coronary artery disease. On NS this consumer started treatment with Plavix (dosage: NA). The following drugs were being taken at the same time:
  • Coraspin
  • Atorvastatin Calcium
  • Delix
  • Oral Antidiabetics
  • Calcium Channel Blockers
  • Beta Blocking Agents
  • Digoxin
  • Nebivolol Hydrochloride
When using Plavix, the patient experienced the following unwanted symptoms/side effects: ArrhythmiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Arrhythmia, may become evident only after a product is in use by the general population.
Plavix Side Effect Report#9910103
Stent Placement, Gastrointestinal Disorder
This Stent Placement side effect was reported by a consumer or non-health professional from US. A male patient (weight:NA) experienced the following symptoms/conditions: coronary artery disease,stent placement.The patient was prescribed Plavix (drug dosage: NA), which was initiated on 2004. Concurrently used drugs: NA..After starting to take Plavix the consumer reported adverse symptoms, such as: Stent Placement, Gastrointestinal DisorderThese side effects may potentially be related to Plavix. The patient was hospitalized.
Plavix Side Effect Report#9908446
Iron Deficiency Anaemia, Shock Haemorrhagic, Pulseless Electrical Activity, Cardiac Arrest, Obstructive Airways Disorder, Thrombosis
This is a report of a 65-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: atrial fibrillation, who was treated with Plavix (dosage: Chronic, start time: NS), combined with:
  • Asa (Chronic)
  • Aleve
  • Coreg
  • Lasix
  • Mag Ox
  • Kcl
and developed a serious reaction and side effect(s): Iron Deficiency Anaemia, Shock Haemorrhagic, Pulseless Electrical Activity, Cardiac Arrest, Obstructive Airways Disorder, Thrombosis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Plavix treatment in female patients, resulting in Iron Deficiency Anaemia side effect. The patient was hospitalized.
Plavix Side Effect Report#9908408
Haemorrhagic Anaemia, Duodenal Ulcer Haemorrhage
This report suggests a potential Plavix Haemorrhagic Anaemia side effect(s) that can have serious consequences. A 75-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: coronary endarterectomy,transient ischaemic attack and used Plavix (dosage: Recent) starting NS. After starting Plavix the patient began experiencing various side effects, including: Haemorrhagic Anaemia, Duodenal Ulcer HaemorrhageAdditional drugs used concurrently: NA.The patient was hospitalized. Although Plavix demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Haemorrhagic Anaemia, may still occur.
Plavix Side Effect Report#9906629
Melaena, Iron Deficiency Anaemia
This Melaena problem was reported by a health professional from FR. A 59-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: thromboangiitis obliterans. On NS this consumer started treatment with Plavix (dosage: NA). The following drugs were being taken at the same time:
  • Perindopril
  • Bisoprolol
  • Lodales
  • Novomix
  • Actrapid
When using Plavix, the patient experienced the following unwanted symptoms/side effects: Melaena, Iron Deficiency AnaemiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Melaena, may become evident only after a product is in use by the general population.
Plavix Side Effect Report#9904830
Loss Of Consciousness
This Loss Of Consciousness side effect was reported by a health professional from TW. A 73-year-old female patient (weight:NA) experienced the following symptoms/conditions: myocardial ischaemia.The patient was prescribed Plavix (drug dosage: NA), which was initiated on
Jan 10, 2013. Concurrently used drugs:
  • Bokey
.After starting to take Plavix the consumer reported adverse symptoms, such as: Loss Of ConsciousnessThese side effects may potentially be related to Plavix. The patient was hospitalized.
Plavix Side Effect Report#9897449
Chronic Myeloid Leukaemia, Malaise, Diarrhoea, Abdominal Pain Upper, Vomiting
This is a report of a 81-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Plavix (dosage: NA, start time: NS), combined with:
  • Sprycel (Every Other Day 2 Weeks.)
  • Sprycel (Every Other Day.)
  • Amlodipine Besilate
  • Metoprolol
  • Lisinopril
  • Synthroid
  • Fluoxetine
  • Aspirin
and developed a serious reaction and side effect(s): Chronic Myeloid Leukaemia, Malaise, Diarrhoea, Abdominal Pain Upper, Vomiting after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Plavix treatment in female patients, resulting in Chronic Myeloid Leukaemia side effect.


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The appearance of Plavix on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Plavix Side Effects for Women?

Women Side Effects Reports
Contusion 168
Dyspnoea 135
Asthenia 117
Cerebrovascular Accident 117
Anaemia 110
Myocardial Infarction 107
Dizziness 103
Death 101
Gastrointestinal Haemorrhage 96
Fall 89

What are common Plavix Side Effects for Men?

Men Side Effects Reports
Myocardial Infarction 189
Anaemia 153
Death 137
Dyspnoea 134
Asthenia 129
Chest Pain 126
Gastrointestinal Haemorrhage 106
Haemorrhage 102
Dizziness 100
Cerebrovascular Accident 97

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Plavix reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Plavix Safety Alerts, Active Ingredients, Usage Information

    NDC 16590-288
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name PLAVIX
    Name CLOPIDOGREL BISULFATE
    Dosage Form TABLET, FILM COATED
    Route ORAL
    On market since 19000101
    Labeler STAT RX USA LLC
    Active Ingredient(s) CLOPIDOGREL BISULFATE
    Strength(s) 75
    Unit(s) mg/1
    Pharma Class Decreased Platelet Aggregation [PE],P2Y12 Platelet Inhibitor [EPC],P2Y12 Receptor Antagonists [MoA]

    Plavix Dosage, Warnings, Usage.

    Side Effects reported to FDA: 5660

    Plavix safety alerts: 2010 2009

    Reported deaths: 1411

    Reported hospitalizations: 3016

    Plavix (clopidogrel): Reduced effectiveness in patients who are poor metabolizers of the drug

    Audience: Cardiology healthcare professionals, patients

    [Posted 03/12/2010] FDA notified healthcare professionals and patients that a Boxed Warning has been added to the prescribing information for Plavix, an anti-blood clotting medication. The Boxed Warning in the drug label will include information to:

    • Warn about reduced effectiveness in patients who are poor metabolizers of Plavix. Poor metabolizers do not effectively convert Plavix to its active form in the body.
    • Inform healthcare professionals that tests are available to identify genetic differences in CYP2C19 function.
    • Advise healthcare professionals to consider use of other anti-platelet medications or alternative dosing strategies for Plavix in patients identified as poor metabolizers.

    Plavix is given to reduce the risk of heart attack, unstable angina, stroke, and cardiovascular death in patients with cardiovascular disease. Plavix works by decreasing the activity of blood cells called platelets, making platelets less likely to form blood clots. A data summary and additional information for healthcare professionals and patients are provided in the linked Drug Safety Communication.

    [03/12/2010 - Drug Safety Communication: Reduced effectiveness of Plavix (clopidogrel) - FDA]
    [03/12/2010 - Information on Clopidogrel Bisulfate (marketed as Plavix) - FDA]

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